Identification of immune-related LncRNA for predicting prognosis and immunotherapeutic response in bladder cancer.
Identification of immune-related LncRNA for predicting prognosis and immunotherapeutic response in bladder cancer.
复制标题
鉴定用于预测膀胱癌预后和免疫治疗反应的免疫相关 LncRNA
DOI：
10.18632/aging.104115
复制
发表时间：
2020-11-18
期刊：
影响因子：
--
通讯作者：
Zhou L
中科院分区：
文献类型：
--
作者：
Wu Y;Zhang L;He S;Guan B;He A;Yang K;Gong Y;Li X;Zhou L
长链非编码RNA（lncRNA）在肿瘤免疫应答和肿瘤微环境中具有多种功能。为了研究用于预测膀胱癌（BLCA）预后和免疫应答的免疫相关lncRNA（IRlncRNA）特征，我们从癌症基因组图谱（TCGA）数据库中提取BLCA数据。最终，共入组405例病例，在训练集中鉴定出8种预后IRlncRNA（MIR 181 A2 HG、AC114730.3、LINC 00892、PTPRD-AS 1、LINC 01013、MRPL 23-AS 1、LINC 01395、AC002454.1）。计算风险评分，将患者分为高风险组和低风险组，高风险患者的总生存率（OS）往往较差。多变量考克斯回归分析证实，IRlncRNA签名可能是一个独立的预后因素。随后在验证集中确认了结果。此外，该8-IRlncRNA分类器与BLCA的无复发生存期（RFS）相关。功能表征揭示了该签名介导的免疫相关表型。该特征也与免疫细胞浸润相关（即，巨噬细胞M0、M2、TMF、CD 8 T细胞和中性粒细胞）和免疫检查点抑制剂（ICI）免疫治疗相关生物标志物[错配修复（MMR）基因、肿瘤突变负荷（TMB）和免疫检查点基因]。本研究强调了8-IRlncRNA标记作为BLCA预后和免疫应答预测因子的价值。
Long noncoding RNAs (lncRNAs) have multiple functions in the cancer immunity response and the tumor microenvironment. To investigate the immune-related lncRNA (IRlncRNA) signature for predicting prognosis and immunotherapeutic response in bladder cancer (BLCA), we extracted BLCA data from The Cancer Genome Atlas (TCGA) database. Finally, a total of 405 cases were enrolled and 8 prognostic IRlncRNAs (MIR181A2HG, AC114730.3, LINC00892, PTPRD-AS1, LINC01013, MRPL23-AS1, LINC01395, AC002454.1) were identified in the training set. Risk scores were calculated to divide patients into high-risk and low-risk groups, and the high-risk patients tended to have a poor overall survival (OS). Multivariate Cox regression analysis confirmed that the IRlncRNA signature could be an independent prognostic factor. The results were subsequently confirmed in the validating set. Additionally, this 8-IRlncRNA classifier was related to recurrence free survival (RFS) of BLCA. Functional characterization revealed this signature mediated immune-related phenotype. This signature was also associated with immune cell infiltration (i.e., macrophages M0, M2, Tregs, CD8 T cells, and neutrophils) and immune checkpoint inhibitors (ICIs) immunotherapy-related biomarkers [mismatch repair (MMR) genes, tumor mutation burden (TMB) and immune checkpoint genes]. The present study highlighted the value of the 8-IRlncRNA signature as a predictor of prognosis and immunotherapeutic response in BLCA.
登录
查看更多内容
Lnc-chop 促进肿瘤和炎症环境中骨髓源性抑制细胞的免疫抑制功能
影响因子：
4.4
作者：
Gao, Yunhuan;Wang, Tiantian;Yang, Rongcun
通讯作者：
Yang, Rongcun
结合长非编码 RNA 表达谱和临床因素的列线图可预测膀胱癌患者的生存
影响因子：
5.2
作者：
Wang, Yifan;Du, Lutao;Wang, Chuanxin
通讯作者：
Wang, Chuanxin
DOI：
10.1126/science.aan5951
发表时间：
2018-02-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Miao D;Margolis CA;Gao W;Voss MH;Li W;Martini DJ;Norton C;Bossé D;Wankowicz SM;Cullen D;Horak C;Wind-Rotolo M;Tracy A;Giannakis M;Hodi FS;Drake CG;Ball MW;Allaf ME;Snyder A;Hellmann MD;Ho T;Motzer RJ;Signoretti S;Kaelin WG Jr;Choueiri TK;Van Allen EM
通讯作者：
Van Allen EM
影响因子：
4.6
作者：
Chung IH;Lu PH;Lin YH;Tsai MM;Lin YW;Yeh CT;Lin KH
通讯作者：
Lin KH
影响因子：
23.4
作者：
van Dijk N;Funt SA;Blank CU;Powles T;Rosenberg JE;van der Heijden MS
通讯作者：
van der Heijden MS