The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis.
The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and meta-analysis.
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DOI：
10.1186/s12885-016-2733-z
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发表时间：
2016-08-25
期刊：
影响因子：
3.8
通讯作者：
Ramírez-Vélez R
中科院分区：
文献类型：
--
作者：
Meneses-Echávez JF;Jiménez EG;Río-Valle JS;Correa-Bautista JE;Izquierdo M;Ramírez-Vélez R
胰岛素样生长因子S在控制癌细胞增殖、分化和凋亡中起着至关重要的作用。尽管运动对胰岛素样生长因子S的影响还不是很清楚，但运动被认为是改善癌症相关结果和生存的有效干预措施。这项荟萃分析旨在确定运动对乳腺癌幸存者胰岛素样生长因子S系统的调节作用。系统检索截至2014年11月的PUMed、EMBASE、Cochrane Central Register of Control Trials、EMBASE、ClinicalTrials.gov、SPORTDiscus、Lilacs和Scope us数据库。根据德西蒙尼和莱尔德方法，通过Meta分析的随机效应模型计算效应估计值。异质性用I2检验进行评价。使用Pedro评分评估偏倚风险和方法学质量。纳入5个随机对照试验(n = 2 35)。大多数女性都是绝经后。发现高质量和低风险的偏向(平均 = 评分 6.2 ± 1)。运动可显著改善胰岛素样生长因子-I、胰岛素样生长因子-II、胰岛素样生长因子结合蛋白-I、胰岛素结合蛋白-3、胰岛素及胰岛素抵抗(P <； 0.05)。血糖无显著差异。有氧运动可提高胰岛素样生长因子-I、胰岛素样生长因子结合蛋白-3和胰岛素水平。经S检验，未发现发表偏倚的证据(p = 0.12)。运动改善了乳腺癌幸存者的胰岛素样生长因子S。这些发现为运动对乳腺癌幸存者的肿瘤微环境、细胞凋亡和生存的分子效应提供了新的见解。本文的在线版本(doi：10.1186/s12885-0162733-z)包含补充材料，授权用户可以使用。
Insulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancer-related outcomes and survival, although its effects on IGF´s are not well understood. This meta-analysis aimed to determine the effects of exercise in modulating IGF´s system in breast cancer survivors. Databases of PuMed, EMBASE, Cochrane Central Register of Controlled Trials, EMBASE, ClinicalTrials.gov, SPORTDiscus, LILACS and Scopus were systematically searched up to November 2014. Effect estimates were calculated through a random-effects model of meta-analysis according to the DerSimonian and Laird method. Heterogeneity was evaluated with the I2 test. Risk of bias and methodological quality were evaluated using the PEDro score. Five randomized controlled trials (n = 235) were included. Most women were post-menopausal. High-quality and low risk of bias were found (mean PEDro score = 6.2 ± 1). Exercise resulted in significant improvements on IGF-I, IGF-II, IGFBP-I, IGFBP-3, Insulin and Insulin resistance (P < 0.05). Non-significant differences were found for Glucose. Aerobic exercise improved IGF-I, IGFBP-3 and Insulin. No evidence of publication bias was detected by Egger´s test (p = 0.12). Exercise improved IGF´s in breast cancer survivors. These findings provide novel insight regarding the molecular effects of exercise on tumoral microenvironment, apoptosis and survival in breast cancer survivors. The online version of this article (doi:10.1186/s12885-016-2733-z) contains supplementary material, which is available to authorized users.
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影响因子：
3.8
作者：
Meneses-Echávez JF;González-Jiménez E;Ramírez-Vélez R
通讯作者：
Ramírez-Vélez R
DOI：
10.1158/1055-9965.epi-08-0531
发表时间：
2009-01
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Irwin ML;Varma K;Alvarez-Reeves M;Cadmus L;Wiley A;Chung GG;Dipietro L;Mayne ST;Yu H
通讯作者：
Yu H
影响因子：
56.9
作者：
Chan, JM;Stampfer, MJ;Pollak, M
通讯作者：
Pollak, M
DOI：
10.1006/bbrc.1997.7089
发表时间：
1997-08-28
影响因子：
3.1
作者：
Nickerson, T;Huynh, H;Pollak, M
通讯作者：
Pollak, M
影响因子：
6.4
作者：
Duggan, Catherine;Wang, Ching-Yun;Neuhouser, Marian L.;Xiao, Liren;Smith, Ashley Wilder;Reding, Kerryn W.;Baumgartner, Richard N.;Baumgartner, Kathy B.;Bernstein, Leslie;Ballard-Barbash, Rachel;McTiernan, Anne
通讯作者：
McTiernan, Anne