Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis.
Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis.
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DOI：
10.1186/s12885-015-1069-4
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发表时间：
2015-02-21
期刊：
影响因子：
3.8
通讯作者：
Ramírez-Vélez R
中科院分区：
文献类型：
--
作者：
Meneses-Echávez JF;González-Jiménez E;Ramírez-Vélez R
癌症相关疲劳（CRF）是乳腺癌幸存者最常见、最令人痛苦的症状。大约 40% 至 80% 接受积极治疗的癌症患者患有 CRF。锻炼可改善整体生活质量和 CRF；然而，培训方式的具体效果尚不清楚。本研究旨在确定监督运动干预对乳腺癌幸存者 CRF 的综合影响。我们在2013年12月至2014年1月期间检索了PubMed/MEDLINE、EMBASE、Scopus、CENTRAL和CINAHL数据库，没有语言限制。使用 PEDro 评分评估偏倚风险和方法学质量。根据 DerSimonian 和 Laird 方法，使用随机效应模型计算汇总效应。通过 I2 检验评估异质性。最终纳入了九项高质量研究（n = 1156）。监督下的有氧运动在改善乳腺癌幸存者的 CRF 方面比传统护理在统计学上更有效（SMD = −0.51，95%CI -0.81 至 -0.21），且统计异质性较高（P = 0.001；I2 = 75%）。阻力训练对 CRF 也有类似的影响（SMD = −0.41，95%CI -0.76 至 -0.05；P = 0.02；I2 = 64%）。 Meta回归分析显示，运动量参数与CRF的效果估计密切相关。 Egger 的测试表明存在中等程度的发表偏倚证据（P = 0.04）。有监督的运动可以降低 CRF，并且必须在乳腺癌康复环境中实施。高强度运动对于改善乳腺癌女性的 CRF 和整体生活质量是安全有效的。鼓励进一步研究。 CRD42014007223
Cancer-related fatigue (CRF) is the most common and distressing symptom in breast cancer survivors. Approximately 40% to 80% of cancer patients undergoing active treatment suffer from CRF. Exercise improves overall quality of life and CRF; however, the specific effects of the training modalities are not well understood. This study aimed to determine the pooled effects of supervised exercise interventions on CRF in breast cancer survivors. We searched PubMed/MEDLINE, EMBASE, Scopus, CENTRAL and CINAHL databases between December 2013 and January 2014 without language restrictions. Risk of bias and methodological quality were evaluated using the PEDro score. Pooled effects were calculated with a random-effects model according to the DerSimonian and Laird method. Heterogeneity was evaluated with the I2 test. Nine high-quality studies (n = 1156) were finally included. Supervised aerobic exercise was statistically more effective than conventional care in improving CRF among breast cancer survivors (SMD = −0.51, 95%CI −0.81 to −0.21), with high statistical heterogeneity (P = 0.001; I2 = 75%). Similar effects were found for resistance training on CRF (SMD = −0.41, 95%CI −0.76 to −0.05; P = 0.02; I2 = 64%). Meta-regression analysis revealed that exercise volume parameters are closely related with the effect estimates on CRF. Egger’s test suggested moderate evidence of publication bias (P = 0.04). Supervised exercise reduces CRF and must be implemented in breast cancer rehabilitation settings. High-volume exercises are safe and effective in improving CRF and overall quality of life in women with breast cancer. Further research is encouraged. CRD42014007223
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DOI：
10.1016/j.ejon.2004.03.007
发表时间：
2005-03-01
期刊：
European journal of oncology nursing : the official journal of European Oncology Nursing Society
影响因子：
--
作者：
Campbell, Anna;Mutrie, Nanette;Kearney, Nora
通讯作者：
Kearney, Nora
DOI：
10.1249/01.mss.0000175857.84936.1a
发表时间：
2005-11-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Hutnick, NA;Williams, NI;Mastro, AM
通讯作者：
Mastro, AM
影响因子：
3.8
作者：
Groenvold, Mogens;Petersen, Morten Aagaard;Mouridsen, Henning T.
通讯作者：
Mouridsen, Henning T.
影响因子：
2.1
作者：
Ergun, M.;Eyigor, S.;Uslu, R.
通讯作者：
Uslu, R.
DOI：
10.1016/j.apmr.2012.09.008
发表时间：
2013-02-01
影响因子：
4.3
作者：
Cantarero-Villanueva, Irene;Fernandez-Lao, Carolina;Arroyo-Morales, Manuel
通讯作者：
Arroyo-Morales, Manuel