De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation.
De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation.
复制标题
DOI：
10.1038/s41536-023-00281-8
复制
发表时间：
2023-02-23
影响因子：
7.2
通讯作者：
Daniero, James J.
中科院分区：
文献类型：
--
作者：
Pruett, Lauren J.;Kenny, Hannah L.;Swift, William M.;Catallo, Katarina J.;Apsel, Zoe R.;Salopek, Lisa S.;Scumpia, Philip O.;Cottler, Patrick S.;Griffin, Donald R.;Daniero, James J.
生物材料使能的原位非纤维化组织的从头形成将为医生提供重要工具。一个示例性应用，声门闭合不全，是使人衰弱的喉部疾病，其中声带不完全闭合，导致说话和吞咽困难。声门功能不全的优选管理包括通过可注射填充物使声带膨胀，然而，目前的选择具有相关的缺点，包括炎症、加速吸收和异物反应。我们开发了一种新的迭代微孔退火颗粒（MAP）支架，旨在提供持久的增强。在使用兔声带麻痹模型进行14个月的声带增强研究后，大多数MAP支架被与对侧声带组织的纤维化和非纤维化胶原蛋白的混合物匹配的组织从头替换。此外，通过MRI和14个月时相对于临床标准的上级发声功能观察到MAP处理家兔的持续组织增强。
Biomaterial-enabled de novo formation of non-fibrotic tissue in situ would provide an important tool to physicians. One example application, glottic insufficiency, is a debilitating laryngeal disorder wherein vocal folds do not fully close, resulting in difficulty speaking and swallowing. Preferred management of glottic insufficiency includes bulking of vocal folds via injectable fillers, however, the current options have associated drawbacks including inflammation, accelerated resorption, and foreign body response. We developed a novel iteration of microporous annealed particle (MAP) scaffold designed to provide persistent augmentation. Following a 14-month study of vocal fold augmentation using a rabbit vocal paralysis model, most MAP scaffolds were replaced with tissue de novo that matched the mixture of fibrotic and non-fibrotic collagens of the contralateral vocal tissue. Further, persistent tissue augmentation in MAP-treated rabbits was observed via MRI and via superior vocal function at 14 months relative to the clinical standard.
登录
查看更多内容
影响因子：
3.7
作者：
Kwon SK;Kim HB;Song JJ;Cho CG;Park SW;Choi JS;Ryu J;Oh SH;Lee JH
通讯作者：
Lee JH
影响因子：
16.6
作者：
Chen K;Kwon SH;Henn D;Kuehlmann BA;Tevlin R;Bonham CA;Griffin M;Trotsyuk AA;Borrelli MR;Noishiki C;Padmanabhan J;Barrera JA;Maan ZN;Dohi T;Mays CJ;Greco AH;Sivaraj D;Lin JQ;Fehlmann T;Mermin-Bunnell AM;Mittal S;Hu MS;Zamaleeva AI;Keller A;Rajadas J;Longaker MT;Januszyk M;Gurtner GC
通讯作者：
Gurtner GC
DOI：
10.3390/healthcare8030326
发表时间：
2020-09-07
期刊：
Healthcare (Basel, Switzerland)
影响因子：
--
作者：
Hsu CM;Yang MY;Fang TJ;Wu CY;Tsai YT;Chang GH;Tsai MS
通讯作者：
Tsai MS
影响因子：
19
作者：
Pruett, Lauren J.;Jenkins, Christian H.;Griffin, Donald R.
通讯作者：
Griffin, Donald R.
DOI：
10.2147/ccid.s50546
发表时间：
2013-12-12
期刊：
Clinical, cosmetic and investigational dermatology
影响因子：
--
作者：
Funt D;Pavicic T
通讯作者：
Pavicic T