Conditioned reflex release of dopamine in the nucleus accumbens after disruption of the hippocampal formation in rats
Conditioned reflex release of dopamine in the nucleus accumbens after disruption of the hippocampal formation in rats
复制标题
大鼠海马结构破坏后伏隔核中多巴胺的条件反射释放
DOI：
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发表时间：
1998
影响因子：
--
通讯作者：
A. I. Gorbachevskaya
中科院分区：
文献类型：
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作者：
N. B. Saul’skaya;A. I. Gorbachevskaya
采用脑内微透析联合高效液相色谱-电化学检测方法，研究了海马形成损伤的蒙面大鼠情绪条件反应发生和实现过程中伏隔核多巴胺释放的变化。这些研究表明，在双侧向海马区注入伊博tenic酸一个月后，大鼠对情境刺激的情绪反应减弱。在条件反射的发展过程中，伏隔核多巴胺的释放水平比假手术大鼠高，持续时间更长。海马病变大鼠和假手术大鼠在情境刺激条件反射过程中伏隔核多巴胺释放水平相同。
Vital intracerebral microdialysis combined with HPLC with electrochemical detection was used to study changes in dopamine release in the nucleus accumbens during the development and realization of an emotional conditioned response in hooded rats with lesions to the hippocampal formation. These studies showed that one month after bilateral administration of ibotenic acid into the hippocampal formation, rats had weakened emotional responses to contextual stimuli. The process of development of the conditioned reflex was accompanied by higher-level and longer-lasting release of dopamine in the nucleus accumbens than in shamoperated rats. Dopamine release levels in the nucleus accumbens during realization of the conditioned reflex to contextual stimuli in rats with hippocampal lesions and sham-operated rats were identical.
影响因子：
1.9
作者：
PHILLIPS, RG;LEDOUX, JE
通讯作者：
LEDOUX, JE