Sex difference in the effect of obesity on prognosis for patients undergoing percutaneous coronary intervention
Sex difference in the effect of obesity on prognosis for patients undergoing percutaneous coronary intervention
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肥胖对经皮冠状动脉介入治疗患者预后影响的性别差异
DOI：
10.1097/mca.0b013e3283576a3d
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发表时间：
2012-09
影响因子：
1.8
通讯作者：
Zhou, YJ
中科院分区：
文献类型：
--
作者：
Gao, F;Liu, XL;Yu, M;Zhou, YJ
目的 探讨肥胖对接受经皮冠状动脉介入治疗 (PCI) 的男性和女性的长期预后是否有相似的影响。方法我们分别对2004年1月至2006年12月接受药物洗脱支架PCI的3926名男性和2157名女性进行了调查。所有患者根据BMI分为：正常体重（<25 kg/m2）、超重（25-29.9 kg/m2）和肥胖（≥30 kg/m2）。主要终点是主要不良心血管事件（MACE），定义为心源性死亡和非致命性心肌梗死的复合事件。中位随访时间为 26 个月。结果男性肥胖患者的MACE发生率显着高于正常体重和超重患者（6.8% vs. 3.5% vs. 4.2%；P=0.001），而女性则不显着（5.1% vs. 4.4% vs. 4.1%；P=0.684）。 BMI 的进一步分类显示，男性 MACE 风险与 BMI 之间存在线性相关性，与正常体重个体相比，肥胖 I 级（30-34.9 kg/m2）和 II/III 级（≥35 kg/m2）组呈分级增加[风险比 (HR) 1.94； 95% 置信区间 (CI) 1.22–3.06；肥胖I级P=0.005，HR 2.62； 95% CI 1.50–4.56；对于 II/III 级肥胖，P=0.001]。在女性中，肥胖I级组的MACE风险无差异，而肥胖II/III级组与正常体重患者相比显着增加（HR 2.15；95% CI 1.10-4.18；P=0.025）。结论在接受 PCI 的患者中，BMI 与男性和女性发生 MACE 的风险相关。然而，BMI 对女性的影响相对较小。
ObjectivesTo examine whether obesity has a similar effect on long-term prognosis between men and women undergoing a percutaneous coronary intervention (PCI). MethodsWe separately examined 3926 men and 2157 women undergoing PCI with drug-eluting stents between January 2004 and December 2006. All the patients were categorized according to BMI: normal weight (<25 kg/m2), overweight (25–29.9 kg/m2), and obese (≥30 kg/m2). The primary endpoint was major adverse cardiovascular events (MACE), defined as a composite of cardiac death and nonfatal myocardial infarction. The median follow-up was 26 months. ResultsThe MACE rate was significantly higher in obese than in normal-weight and overweight patients among men (6.8 vs. 3.5 vs. 4.2%; P=0.001) but not among women (5.1 vs. 4.4 vs. 4.1%; P=0.684). Further categorization of BMI showed a linear association between the risk of MACE and BMI in men, with a graded increase in obesity grade I (30–34.9 kg/m2) and grade II/III (≥35 kg/m2) groups compared with normal-weight individuals [hazard ratio (HR) 1.94; 95% confidence interval (CI) 1.22–3.06; P=0.005 for obesity grade I and HR 2.62; 95% CI 1.50–4.56; P=0.001 for obesity grade II/III]. In women, the risk of MACE showed no difference in obesity grade I group, whereas there was a significant increase in the obesity grade II/III group compared with normal-weight patients (HR 2.15; 95% CI 1.10–4.18; P=0.025). ConclusionIn patients undergoing PCI, BMI is associated with a risk of MACE in both men and women. However, BMI exerts relatively less effect on women than on men.
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影响因子：
120.7
作者：
Flegal, KM;Carroll, MD;Johnson, CL
通讯作者：
Johnson, CL
DOI：
10.1097/00008483-200003000-00010
发表时间：
1999-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
E. Calle;M. Thun;Jennifer M. Petrelli;C. Rodríguez;C. Heath
通讯作者：
E. Calle;M. Thun;Jennifer M. Petrelli;C. Rodríguez;C. Heath
影响因子：
39.3
作者：
Domanski, Michael J.;Jablonski, Kathleen A.;Braunwald, Eugene
通讯作者：
Braunwald, Eugene
影响因子：
3.5
作者：
G. Fehér;K. Koltai;B. Alkonyi;E. Papp;Z. Keszthelyi;G. Késmárky;K. Tóth
通讯作者：
G. Fehér;K. Koltai;B. Alkonyi;E. Papp;Z. Keszthelyi;G. Késmárky;K. Tóth
DOI：
10.1016/s0735-1097(02)01687-x
发表时间：
2002-03-06
影响因子：
24
作者：
Gurm, HS;Whitlow, PL;BARI Invest
通讯作者：
BARI Invest