Prevention and treatment of Staphylococcus aureus biofilms.
Prevention and treatment of Staphylococcus aureus biofilms.
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DOI：
10.1586/14787210.2015.1100533
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发表时间：
2015
影响因子：
5.7
通讯作者：
Hall-Stoodley L
中科院分区：
文献类型：
--
作者：
Bhattacharya M;Wozniak DJ;Stoodley P;Hall-Stoodley L
金黄色葡萄球菌定植于人体的人造表面和组织表面，导致难以治愈的慢性持续性感染。由于其抗生素不耐受性和表型适应性，它是一种臭名昭著的病原体，而其形成生物膜的能力促进了这两者。金黄色葡萄球菌生物膜挑战了传统的抗感染方法，尤其是抗生素治疗。因此，开发并包括针对金黄色葡萄球菌生物膜感染的并行方法的需求尚未得到满足。本综述讨论了两种广泛的抗感染策略：（1）预防方法（抗生物膜表面涂层，包含生物膜特异性疫苗抗原）； (2) 旨在根除已形成的金黄色葡萄球菌生物膜的方法，特别是那些与植入物感染相关的生物膜。对金黄色葡萄球菌生物膜发育和发病机制的独特性质的了解的进展使人们对金黄色葡萄球菌生物膜靶向抗感染策略越来越乐观。然而，还需要进一步的研究，以看到这些方法对多种临床菌株的金黄色葡萄球菌生物膜引起的不同类型的感染的成功管理和验证。
S. aureus colonizes both artificial and tissue surfaces in humans causing chronic persistent infections that are difficult to cure. It is a notorious pathogen due to its antibiotic recalcitrance and phenotypic adaptability, both of which are facilitated by its ability to develop biofilms. S. aureus biofilms challenge conventional anti-infective approaches, most notably antibiotic therapy. Therefore there is an unmet need to develop and include parallel approaches that target S. aureus biofilm infections. This review discusses two broad anti-infective strategies: (1) preventative approaches (anti-biofilm surface coatings, the inclusion of biofilm-specific vaccine antigens); and (2) approaches aimed at eradicating established S. aureus biofilms, particularly those associated with implant infections. Advances in understanding the distinct nature of S. aureus biofilm development and pathogenesis have led to growing optimism in S. aureus biofilm targeted anti-infective strategies. Further research is needed however, to see the successful administration and validation of these approaches to the diverse types of infections caused by S. aureus biofilms from multiple clinical strains.
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影响因子：
3.7
作者：
Bose JL;Lehman MK;Fey PD;Bayles KW
通讯作者：
Bayles KW
影响因子：
2.1
作者：
Chung, Kenneth K.;Schumacher, James F.;Brennana, Anthony B.
通讯作者：
Brennana, Anthony B.
影响因子：
3
作者：
Abraham, Nabil M.;Lamlertthon, Supaporn;Jefferson, Kimberly K.
通讯作者：
Jefferson, Kimberly K.
影响因子：
3.1
作者：
Brady, Rebecca A.;O'May, Graeme A.;Shirtliff, Mark E.
通讯作者：
Shirtliff, Mark E.
影响因子：
6.4
作者：
Cirioni, O;Giacometti, A;Balaban, N
通讯作者：
Balaban, N