Seawater transfer down-regulates C-type natriuretic peptide-3 expression in prolactin-producing cells of Japanese eel: Negative correlation with plasma chloride concentration
Seawater transfer down-regulates C-type natriuretic peptide-3 expression in prolactin-producing cells of Japanese eel: Negative correlation with plasma chloride concentration
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海水转移下调日本鳗催乳素产生细胞中C型利尿钠肽3的表达：与血浆氯化物浓度呈负相关
DOI：
10.1016/j.mce.2020.110780
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发表时间：
2020
影响因子：
4.1
通讯作者：
Tsukada Takehiro
中科院分区：
文献类型：
--
作者：
Katayama Yukitoshi;Wong Marty Kwok-Shing;Kusakabe Makoto;Fujio Megumi;Takahashi Natsuki;Yaguchi Miku;Tsukada Takehiro
在广盐性鱼类中，心房肽和B型利钠肽是重要的降压调节激素，而C型利钠肽（CNPs）的降压调节功能还有待进一步研究。虽然CNP的4种亚型（CNP 1 -4）主要在脑中表达，但CNP 3在广盐性日本鳗鲡（Anguilla japonica）中存在多器官表达。在这里，我们确定了CNP 3表达细胞，并研究了它们对渗透胁迫的反应。CNP 3在几种内分泌细胞中表达：泌乳素产生细胞（垂体）、胰高血糖素产生细胞（胰腺）和心肌细胞（心脏）。在器官中，PADCNP 3的表达最高，在海水转移后降低，其次是淡水适应（高血糖调节）激素催乳素的降低。我们还发现垂体中CNP 3/催乳素表达与血浆Cl−浓度呈负相关，但与血浆Na+浓度无关。这些结果表明，脑垂体（和胰腺）中的CNP 3与催乳素一起在广盐鳗的淡水适应中起着关键作用。
In euryhaline fishes, atrial and B-type natriuretic peptides are important hormones in hypo-osmoregulation, whereas osmoregulatory functions of C-type natriuretic peptides (CNPs) remain to be investigated. Although four CNP isoforms (CNP1-4) are mainly expressed in the brain, multiorgan expression of CNP3 was found in euryhaline Japanese eel,Anguilla japonica. Here we identified the CNP3-expressing cells and examined their response to osmotic stress in eel. CNP3 was expressed in several endocrine cells: prolactin-producing cells (pituitary), glucagon-producing cells (pancreas), and cardiomyocytes (heart). Pituitary CNP3 expression was the highest among organs and was decreased following seawater transfer, followed by a decrease in the freshwater-adaptating (hyper-osmoregulatory) hormone prolactin. We also showed the negative correlation between CNP3/prolactin expression in the pituitary and plasma Cl−concentration, but not for plasma Na+concentration. These results suggest that CNP3 in the pituitary (and pancreas) plays a critical role in freshwater adaptation of euryhaline eel together with prolactin.
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C 型利钠肽通过下丘脑作用位点刺激催乳素分泌
影响因子：
3.2
作者：
F. Huang;K. Skala;W. Samson
通讯作者：
W. Samson
DOI：
10.2108/zsj.22.77
发表时间：
2005
期刊：
--
影响因子：
--
作者：
T. Tsukada;J. Cliff Rankin;Y. Takei
通讯作者：
T. Tsukada;J. Cliff Rankin;Y. Takei
影响因子：
2.7
作者：
Breves, Jason P.;McCormick, Stephen D.;Karlstrom, Rolf O.
通讯作者：
Karlstrom, Rolf O.
影响因子：
2.7
作者：
A. Seale;J. C. Fiess;Tetsuya Hirano;Ian M. Cooke;E. Grau
通讯作者：
A. Seale;J. C. Fiess;Tetsuya Hirano;Ian M. Cooke;E. Grau
C型利尿钠肽
DOI：
--
发表时间：
2021
期刊：
Handbook of Hormones
影响因子：
--
作者：
T. Tsukada
通讯作者：
T. Tsukada