Prolactin and teleost ionocytes: new insights into cellular and molecular targets of prolactin in vertebrate epithelia.
Prolactin and teleost ionocytes: new insights into cellular and molecular targets of prolactin in vertebrate epithelia.
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DOI：
10.1016/j.ygcen.2013.12.014
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发表时间：
2014-07-01
影响因子：
2.7
通讯作者：
Karlstrom, Rolf O.
中科院分区：
文献类型：
--
作者：
Breves, Jason P.;McCormick, Stephen D.;Karlstrom, Rolf O.
肽激素催乳素是由脊椎动物脑垂体产生的功能多样的激素。过去六十年的比较研究表明，在脊椎动物中，催乳素的保守功能是调节各种组织中的离子和水的运输，包括负责整个生物体离子稳态的组织。在硬骨鱼中，催乳素被确定为“淡水适应激素”，通过作用于鳃、肾、肠和膀胱促进离子保存和水分泌过程。在哺乳动物中，已知催乳素调节肾、肠、乳腺和羊膜上皮，其功能障碍与性腺功能减退、不育和代谢紊乱有关。直到最近，我们对鱼类催乳素作用的细胞机制的理解一直受到缺乏分子工具来定义和研究离子细胞的阻碍，离子细胞是控制鳃和表皮上皮细胞活性离子运输的专门细胞。在这里，我们回顾工作硬骨鱼模型表明，催乳素调节离子平衡，通过离子转运蛋白，紧密连接蛋白，和离子细胞的水通道的行动，并讨论我们的理解在遗传和胚胎访问斑马鱼（斑马鱼）的离子细胞功能的最新进展。鉴于内分泌和泌乳素调节系统的高度进化保守性，这些硬骨鱼模型的研究有助于深入了解催乳素如何参与整个脊椎动物谱系的泌乳素调节系统的发育、功能和功能障碍。
The peptide hormone prolactin is a functionally versatile hormone produced by the vertebrate pituitary. Comparative studies over the last six decades have revealed that a conserved function for prolactin across vertebrates is the regulation of ion and water transport in a variety of tissues including those responsible for whole-organism ion homeostasis. In teleost fishes, prolactin was identified as the “freshwater-adapting hormone”, promoting ion-conserving and water-secreting processes by acting on the gill, kidney, gut and urinary bladder. In mammals, prolactin is known to regulate renal, intestinal, mammary and amniotic epithelia, with dysfunction linked to hypogonadism, infertility, and metabolic disorders. Until recently, our understanding of the cellular mechanisms of prolactin action in fishes has been hampered by a paucity of molecular tools to define and study ionocytes, specialized cells that control active ion transport across branchial and epidermal epithelia. Here we review work in teleost models indicating that prolactin regulates ion balance through action on ion transporters, tight-junction proteins, and water channels in ionocytes, and discuss recent advances in our understanding of ionocyte function in the genetically and embryonically accessible zebrafish (Danio rerio). Given the high degree of evolutionary conservation in endocrine and osmoregulatory systems, these studies in teleost models are contributing novel mechanistic insight into how prolactin participates in the development, function, and dysfunction of osmoregulatory systems across the vertebrate lineage.
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影响因子：
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作者：
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发表时间：
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期刊：
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影响因子：
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发表时间：
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通讯作者：
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DOI：
10.1016/j.cbpa.2012.09.011
发表时间：
2013-01-01
影响因子：
2.3
作者：
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通讯作者：
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