Nickel-dependent metalloenzymes.
Nickel-dependent metalloenzymes.
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DOI:
10.1016/j.abb.2013.09.002
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发表时间:
2014-02-15
影响因子:
3.9
通讯作者:
Hausinger, Robert P.
中科院分区:
文献类型:
--
作者:
Boer, Jodi L.;Mulrooney, Scott B.;Hausinger, Robert P.
This review describes the functions, structures, and mechanisms of nine nickel-containing enzymes: glyoxalase I, acireductone dioxygenase, urease, superoxide dismutase, [NiFe]-hydrogenase, carbon monoxide dehydrogenase, acetyl-coenzyme A synthase/decarbonylase, methyl-coenzyme M reductase, and lactate racemase. These enzymes catalyze their various chemistries by using metallocenters of diverse structures, including mononuclear nickel, dinuclear nickel, nickel-iron heterodinuclear sites, more complex nickel-containing clusters, and nickel-tetrapyrroles. Selected other enzymes are active with nickel, but the physiological relevance of this metal specificity is unclear. Additional nickel-containing proteins of undefined function have been identified.
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