Roles of Long Noncoding RNAs in Recurrence and Metastasis of Radiotherapy-Resistant Cancer Stem Cells.
Roles of Long Noncoding RNAs in Recurrence and Metastasis of Radiotherapy-Resistant Cancer Stem Cells.
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DOI：
10.3390/ijms18091903
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发表时间：
2017-09-05
影响因子：
5.6
通讯作者：
Lin KH
中科院分区：
文献类型：
--
作者：
Chi HC;Tsai CY;Tsai MM;Yeh CT;Lin KH
放射治疗是一种行之有效的治疗方案，用于治疗全球至少一半的癌症患者。癌症的放射抗性或无法用放射治疗某些肿瘤类型与局部侵袭、转移和不良预后相关。因此，阐明放射抗性的生物学特性对于确保制定有效策略来解决这一问题至关重要，这仍然是一个紧迫的医学问题。癌症干细胞 (CSC) 包含一小群肿瘤细胞，构成大多数癌细胞类型的起源。 CSC 实际上对放射治疗具有抵抗力，因此会导致复发和疾病进展。转移是癌症放射治疗耐药性中日益严重的问题，并且与几种癌症类型的发病率和死亡率密切相关。越来越多的证据表明，辐射会诱导上皮-间质转化 (EMT)，同时增加癌症复发、转移和 CSC 生成。 CSC被认为是转移的基础。先前的研究表明，CSC 以直接或间接的方式促进转移的产生。此外，CSC 的异质性可能是造成器官特异性和转移相当复杂的原因。长非编码RNA (lncRNA) 是一类长度超过200 个核苷酸的非编码分子，参与多种癌症类型的发生和进展。最近，lncRNA 作为癌症进展和转移的新型关键调节因子引起了相当大的关注。在当前的综述中，我们讨论了放疗后lncRNA介导的CSC调节、它们与肿瘤转移的关系以及在癌症放射抗性中的意义。
Radiotherapy is a well-established therapeutic regimen applied to treat at least half of all cancer patients worldwide. Radioresistance of cancers or failure to treat certain tumor types with radiation is associated with enhanced local invasion, metastasis and poor prognosis. Elucidation of the biological characteristics underlying radioresistance is therefore critical to ensure the development of effective strategies to resolve this issue, which remains an urgent medical problem. Cancer stem cells (CSCs) comprise a small population of tumor cells that constitute the origin of most cancer cell types. CSCs are virtually resistant to radiotherapy, and consequently contribute to recurrence and disease progression. Metastasis is an increasing problem in resistance to cancer radiotherapy and closely associated with the morbidity and mortality rates of several cancer types. Accumulating evidence has demonstrated that radiation induces epithelial–mesenchymal transition (EMT) accompanied by increased cancer recurrence, metastasis and CSC generation. CSCs are believed to serve as the basis of metastasis. Previous studies indicate that CSCs contribute to the generation of metastasis, either in a direct or indirect manner. Moreover, the heterogeneity of CSCs may be responsible for organ specificity and considerable complexity of metastases. Long noncoding RNAs (lncRNAs) are a class of noncoding molecules over 200 nucleotides in length involved in the initiation and progression of several cancer types. Recently, lncRNAs have attracted considerable attention as novel critical regulators of cancer progression and metastasis. In the current review, we have discussed lncRNA-mediated regulation of CSCs following radiotherapy, their association with tumor metastasis and significance in radioresistance of cancer.
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影响因子：
6.2
作者：
Delaney, G;Jacob, S;Barton, M
通讯作者：
Barton, M
DOI：
10.1002/pros.22527
发表时间：
2012-12-01
期刊：
The Prostate
影响因子：
--
作者：
Cho YM;Kim YS;Kang MJ;Farrar WL;Hurt EM
通讯作者：
Hurt EM
影响因子：
--
作者：
Brodie S;Lee HK;Jiang W;Cazacu S;Xiang C;Poisson LM;Datta I;Kalkanis S;Ginsberg D;Brodie C
通讯作者：
Brodie C
影响因子：
5.2
作者：
Alves, Cleidson Padua;Fonseca, Aline Simoneti;Silva, Wilson Araujo, Jr.
通讯作者：
Silva, Wilson Araujo, Jr.
影响因子：
11.4
作者：
Blume, C. J.;Hotz-Wagenblatt, A.;Zenz, T.
通讯作者：
Zenz, T.