Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage.
Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage.
复制标题
DOI：
10.1038/s41467-021-25441-6
复制
发表时间：
2021-08-25
影响因子：
16.6
通讯作者：
Sheth KN
中科院分区：
文献类型：
--
作者：
Mazurek MH;Cahn BA;Yuen MM;Prabhat AM;Chavva IR;Shah JT;Crawford AL;Welch EB;Rothberg J;Sacolick L;Poole M;Wira C;Matouk CC;Ward A;Timario N;Leasure A;Beekman R;Peng TJ;Witsch J;Antonios JP;Falcone GJ;Gobeske KT;Petersen N;Schindler J;Sansing L;Gilmore EJ;Hwang DY;Kim JA;Malhotra A;Sze G;Rosen MS;Kimberly WT;Sheth KN
脑放射学检查是中风护理途径的关键决定因素。可解释的神经影像学检查对于发现脑内出血（ICH）是必不可少的。传统的磁共振成像（MRI）在高磁场强度（1.5-3 T）下工作，这需要一个访问控制的环境，使得MRI通常无法访问。我们证明了使用低场MRI（0.064 T）进行ICH评价。患者于2018年7月至2020年11月在耶鲁纽黑文医院使用常规神经成像（非造影计算机断层扫描（CT）或1.5/3 T MRI）和便携式MRI（pMRI）进行成像。两名委员会认证的神经放射学家共评估了144例pMRI检查（56例ICH，48例急性缺血性卒中，40例健康对照），一名ICH成像核心实验室研究员审查了不一致的病例。在56例病例中，评定者正确检测到45例ICH（80.4%灵敏度，95%CI：[0.68-0.90]）。在88例病例中，85例正确识别出血液阴性病例（96.6%特异性，95%CI：[0.90-0.99]）。pMRI上手动分割的血肿体积和ABC/2估计体积与常规成像体积相关（ICC = 0.955，p = 1.69e-30和ICC = 0.875，p = 1.66e-8）。pMRI上测量的血肿体积与出院时手动和ABC/2体积的NIH卒中量表（NIHSS）和临床结局（mRS）相关。低场pMRI可能有助于将先进的MRI技术带到资源有限的环境中。传统的磁共振成像（MRI）在高磁场强度下工作，需要严格的访问控制环境，使得MRI通常无法访问。在这里，作者提出了一种便携式低场MRI设备，检测脑出血与高精度。
Radiological examination of the brain is a critical determinant of stroke care pathways. Accessible neuroimaging is essential to detect the presence of intracerebral hemorrhage (ICH). Conventional magnetic resonance imaging (MRI) operates at high magnetic field strength (1.5–3 T), which requires an access-controlled environment, rendering MRI often inaccessible. We demonstrate the use of a low-field MRI (0.064 T) for ICH evaluation. Patients were imaged using conventional neuroimaging (non-contrast computerized tomography (CT) or 1.5/3 T MRI) and portable MRI (pMRI) at Yale New Haven Hospital from July 2018 to November 2020. Two board-certified neuroradiologists evaluated a total of 144 pMRI examinations (56 ICH, 48 acute ischemic stroke, 40 healthy controls) and one ICH imaging core lab researcher reviewed the cases of disagreement. Raters correctly detected ICH in 45 of 56 cases (80.4% sensitivity, 95%CI: [0.68–0.90]). Blood-negative cases were correctly identified in 85 of 88 cases (96.6% specificity, 95%CI: [0.90–0.99]). Manually segmented hematoma volumes and ABC/2 estimated volumes on pMRI correlate with conventional imaging volumes (ICC = 0.955, p = 1.69e-30 and ICC = 0.875, p = 1.66e-8, respectively). Hematoma volumes measured on pMRI correlate with NIH stroke scale (NIHSS) and clinical outcome (mRS) at discharge for manual and ABC/2 volumes. Low-field pMRI may be useful in bringing advanced MRI technology to resource-limited settings. Conventional magnetic resonance imaging (MRI) operates at a high magnetic field strength and requires a strict access-controlled environment, making MRI often inaccessible. Here, the authors present a portable low-field MRI device that detects intracerebral hemorrhage with high accuracy.
登录
查看更多内容
影响因子：
8.2
作者：
An SJ;Kim TJ;Yoon BW
通讯作者：
Yoon BW
影响因子：
19.7
作者：
Campbell-Washburn, Adrienne E.;Ramasawmy, Rajiv;Balaban, Robert S.
通讯作者：
Balaban, Robert S.
DOI：
10.1007/s00068-009-9127-8
发表时间：
2010-08-01
影响因子：
2.1
作者：
Agrawal, Shruti;Hulme, Sara-Louise;Brierley, Joe
通讯作者：
Brierley, Joe
DOI：
10.1348/000711006x126600
发表时间：
2008-05-01
影响因子：
2.6
作者：
Gwet, Kilem Li
通讯作者：
Gwet, Kilem Li
影响因子：
8.3
作者：
BRODERICK, JP;BROTT, TG;HUSTER, G
通讯作者：
HUSTER, G