Three-week exercise and protein intake immediately after exercise increases the 6-min walking distance with simultaneously improved plasma volume in patients with chronic cerebrovascular disease: a preliminary prospective study.
Three-week exercise and protein intake immediately after exercise increases the 6-min walking distance with simultaneously improved plasma volume in patients with chronic cerebrovascular disease: a preliminary prospective study.
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DOI：
10.1186/s13102-022-00429-x
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发表时间：
2022-03-15
期刊：
影响因子：
--
通讯作者：
Tajima F
中科院分区：
文献类型：
--
作者：
Sato C;Kamijo YI;Sakurai Y;Araki S;Sakata Y;Ishigame A;Murai K;Yoshioka I;Tajima F
血容量（BV）是慢性中风患者身体耐力的关键因素，而血容量过多会加重这些患者的高血压。这项前瞻性研究评估了为期 3 周的每次运动后立即补充蛋白质的康复治疗是否会改善血浆容量 (PV) 和 BV 以及身体耐力，而不会使高血压恶化。接受为期 3 周康复计划的慢性脑血管疾病门诊患者每次运动后 30 分钟内食用高蛋白果冻（干预组 [PG]；n = 8；10 g 蛋白质）或无蛋白果冻（对照组 [CG]；n = 8）。评估PV和BV，同时测量干预前后的6分钟步行距离（6MWD）、峰值耗氧量（VO2peak）、膝关节伸展强度和静息血压。采用双向方差分析来判断时间 × 组是否存在交互作用。干预前后或组间的差异通过事后检验（Tukey’s检验）在P < 0.05水平上进行。 6MWD 仅在 PG 中增加（P = 0.001；组别和时间的相互作用，P = 0.037）。 PV 和 BV 仅在 PG 中增加（P < 0.05）。两组瘫痪肢体的摄氧量峰值和膝关节伸展力量均有所增加（P < 0.05）。干预后静息血压并未恶化。在慢性中风后患者中，3周康复结合运动后立即摄入蛋白质可增加6MWD，同时PV和BV增加，但不会增加静息血压。本方案对于患有慢性脑血管疾病的门诊患者是可接受且有效的。注册名称 检验补充蛋白质对慢性中风患者康复干预期间功能改善的影响 试验注册号 UMIN000028009；注册日期：2017年6月30日。这项研究是前瞻性注册的。在线版本包含可在 10.1186/s13102-022-00429-x 获取的补充材料。
Blood volume (BV) is a critical factor for physical endurance in chronic stroke patients, while hypervolemia can worsen hypertension in these patients. This prospective study assessed whether rehabilitation combined with protein supplementation immediately after each exercise for 3 weeks would improve plasma volume (PV) and BV as well as physical endurance without worsening hypertension. Ambulatory patients with chronic cerebrovascular disease who received a 3-week rehabilitation program with high protein jelly (intervention group [PG]; n = 8; 10-g protein) or protein-free jelly (control group [CG]; n = 8) consumed within 30 min after each exercise. PV and BV were assessed while measuring the 6-min walking distance (6MWD), peak oxygen consumption (VO2peak), strength of knee extension, and resting blood pressure before and after the intervention. Two-way ANOVA was used to determine whether there was an interaction of time × group. The difference between before and after intervention or between the groups by post-hoc test (Tukey’s test) at the level of P < 0.05. The 6MWD increased only in the PG (P = 0.001; an interaction of Group and Time, P = 0.037). PV and BV increased only in the PG (P < 0.05). VO2peak and strength of knee extension in the paralysed limb increased in both groups (P < 0.05). The resting blood pressure did not worsen after the intervention. In chronic post-stroke patients, 3-week rehabilitation combined with protein intake immediately after exercise increased 6MWD simultaneously with increased PV and BV, but it did not increase resting blood pressure. The present regimen is acceptable and effective for ambulatory patients with chronic cerebrovascular disease. Name of the registry Examining effects of protein supplementation on functional improvement during rehabilitation intervention in chronic stroke patients Trial registration number UMIN000028009; date of registration: 30/06/2017. This study was registered prospectively. The online version contains supplementary material available at 10.1186/s13102-022-00429-x.
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DOI：
10.1016/s0003-9993(97)90005-8
发表时间：
1997-01-01
影响因子：
4.3
作者：
Bohannon, RW
通讯作者：
Bohannon, RW
影响因子：
3.1
作者：
Convertino, Victor A.
通讯作者：
Convertino, Victor A.
DOI：
10.1093/gerona/glq137
发表时间：
2010-12-01
影响因子：
5.1
作者：
Fiser, Wesley M.;Hays, Nicholas P.;Evans, William J.
通讯作者：
Evans, William J.
影响因子：
3.5
作者：
Flansbjer, UB;Holmbäck, AM;Lexell, J
通讯作者：
Lexell, J
影响因子：
3
作者：
Byun, Seung-Deuk;Jung, Tae-Du;Lee, Yang-Soo
通讯作者：
Lee, Yang-Soo