MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome.
MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome.
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DOI：
10.1186/1471-2407-10-497
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发表时间：
2010-09-17
期刊：
影响因子：
3.8
通讯作者：
O'Brien PM
中科院分区：
文献类型：
--
作者：
Byrne JA;Maleki S;Hardy JR;Gloss BS;Murali R;Scurry JP;Fanayan S;Emmanuel C;Hacker NF;Sutherland RL;Defazio A;O'Brien PM
四次跨膜的 MAL2 蛋白在乳腺癌中经常过度表达，并且 MAL2 过度表达与染色体 8q24.12 上相应基因座的获得有关。独立表达微阵列研究预测 MAL2 在卵巢癌中过度表达，但这些尚未得到证实。 MAL2 结合肿瘤蛋白 D52 (TPD52)，该蛋白在卵巢癌中经常过度表达，但 MAL2 和 TPD52 过度表达的临床意义尚不清楚。使用组织微阵列切片（包括良性、交界性和恶性上皮性卵巢肿瘤）对 MAL2 和 TPD52 表达进行免疫组织化学分析。通过目视和数字评估免疫组织化学染色强度和分布。与浆液性交界性肿瘤相比，MAL2 和 TPD52 在高级别浆液性癌中显着过表达。相对于其他组织学亚型，MAL2 表达在浆液性癌中最高，而 TPD52 表达在透明细胞癌中最高。 MAL2 表达与患者生存无关，但高水平 TPD52 染色与 III 期浆液性卵巢癌患者总体生存改善显着相关（对数秩检验，p < 0.001；n = 124），并且是整个癌症队列中生存的独立预测因子（风险比 (HR)，0.498；95% 置信区间 (CI)，0.34-0.728；p < 0.001；p < 0.001）。 n = 221）和浆液性癌（HR，0.440；95% CI，0.294-0.658；p < 0.001；n = 182）。 MAL2 在卵巢癌中经常过度表达，TPD52 过度表达是一个有利的独立预后标志物，在卵巢癌患者的治疗中具有潜在价值。
The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours. MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas. MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p < 0.001; n = 124) and was an independent predictor of survival in the overall carcinoma cohort (hazard ratio (HR), 0.498; 95% confidence interval (CI), 0.34-0.728; p < 0.001; n = 221), and in serous carcinomas (HR, 0.440; 95% CI, 0.294-0.658; p < 0.001; n = 182). MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients.
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DOI：
10.1038/nrc2644
发表时间：
2009-06
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
7
作者：
Lee, HK;Hsu, AK;Pavlidis, P
通讯作者：
Pavlidis, P
影响因子：
3.8
作者：
Han W;Han MR;Kang JJ;Bae JY;Lee JH;Bae YJ;Lee JE;Shin HJ;Hwang KT;Hwang SE;Kim SW;Noh DY
通讯作者：
Noh DY
影响因子：
11.2
作者：
Hendrix, ND;Wu, R;Cho, KR
通讯作者：
Cho, KR
影响因子：
9.6
作者：
Hoang, CD;D'Cunha, J;Kratzke, RA
通讯作者：
Kratzke, RA