Displacement and hybridization reactions in aptamer-functionalized hydrogels for biomimetic protein release and signal transduction.
Displacement and hybridization reactions in aptamer-functionalized hydrogels for biomimetic protein release and signal transduction.
复制标题
适配体功能化水凝胶中用于仿生蛋白释放和信号转导的位移和杂交反应。
DOI：
10.1039/c7sc03023a
复制
发表时间：
2017-11-01
期刊：
影响因子：
8.4
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Lai J;Li S;Shi X;Coyne J;Zhao N;Dong F;Mao Y;Wang Y
Combinatorial external and internal triggering events enable hydrogel to control protein release by mimicking signal transduction of the cell in response to metabolism. A variety of hydrogels have been synthesized for controlling the release of signaling molecules in applications such as drug delivery and regenerative medicine. However, it remains challenging to synthesize hydrogels with the ability to control the release of signaling molecules sequentially or periodically under physiological conditions as living cells do in response to the variation of metabolism. The purpose of this work was to study a novel biomimetic hydrogel system with the ability of recapitulating the procedure of cellular signal transduction and controlling the sequential release of signaling molecules under physiological conditions. In the presence of a small chemical, the signaling molecule is regulated to change from a DNA-bound state to a free state and the freed signaling molecule is able to regulate intracellular signal transduction and cell migration. Moreover, periodic exposure of the hydrogel system to the small chemical leads to sequential protein release. Since signaling molecules are important for every activity of the cell, this hydrogel system holds potential as a metabolism-responsive platform for controlled release of signaling molecules and cell regulation in various applications.
登录
查看更多内容
聚乙二醇作为一种有前景的脊髓损伤修复合成材料
影响因子：
6.1
作者：
Kong XB;Tang QY;Chen XY;Tu Y;Sun SZ;Sun ZL
通讯作者：
Sun ZL
pH 触发、快速响应的 DNA 水凝胶
影响因子：
16.6
作者：
Cheng, Enjun;Xing, Yongzheng;Liu, Dongsheng
通讯作者：
Liu, Dongsheng
影响因子：
--
作者：
Lin, CH;Patel, DJ
通讯作者：
Patel, DJ
影响因子：
11.8
作者：
Franz, CM;Jones, GE;Ridley, AJ
通讯作者：
Ridley, AJ
影响因子：
14.9
作者：
Li, QQ;Luan, GY;Liang, JX
通讯作者：
Liang, JX