Free mobilization and low- to high-intensity exercise in immobilization-induced muscle atrophy.
Free mobilization and low- to high-intensity exercise in immobilization-induced muscle atrophy.
复制标题
自由活动和低至高强度运动治疗固定引起的肌肉萎缩。
DOI：
--
复制
发表时间：
1998
影响因子：
3.3
通讯作者：
M. Järvinen
中科院分区：
文献类型：
--
作者：
Pekka Kannus;László Józsa;T. Järvinen;M. Kvist;T. Vieno;T. Järvinen;A. Natri;M. Järvinen
固定3wk后，观察自由笼活动和低强度和大强度跑台运动(8wk)对雄性SD大鼠比目鱼肌和腓肠肌的形态和组织化学的影响。在两个肌肉中，制动产生了肌肉内结缔组织的平均百分比面积显著增加(P<；0.001)(比目鱼肌：18.9%在固定的左后肢对3.6%在未固定的右后肢)和有病理改变的肌肉纤维的相对数量(比目鱼肌：在固定的后肢：66%对对照的6%)，同时显著(P<；0.001)肌内毛细血管密度(比目鱼肌：固定后肢的平均毛细血管密度仅为非固定后肢的63%)和肌纤维大小(比目鱼肌I型纤维：固定后肢的平均纤维直径仅为非固定后肢的69%)减少。这些变化中的许多不能通过自由活动来纠正，而低强度和高强度跑步机跑步明显地将变化恢复到对照水平，高强度跑步组的效果最完全。综上所述，这些发现表明，如果运动训练加强再动员，大鼠小腿肌肉由制动引起的病理结构和组织化学变化在很大程度上是可逆的现象。在这方面，高强度运动似乎比低强度运动更有益。
After 3 wk of immobilization, the effects of free cage activity and low- and high-intensity treadmill running (8 wk) on the morphology and histochemistry of the soleus and gastrocnemius muscles in male Sprague-Dawley rats were investigated. In both muscles, immobilization produced a significant (P < 0.001) increase in the mean percent area of intramuscular connective tissue (soleus: 18.9% in immobilized left hindlimb vs. 3.6% in nonimmobilized right hindlimb) and in the relative number of muscle fibers with pathological alterations (soleus: 66% in immobilized hindlimb vs. 6% in control), with a simultaneous significant (P < 0.001) decrease in the intramuscular capillary density (soleus: mean capillary density in the immobilized hindlimb only 63% of that in the nonimmobilized hindlimb) and muscle fiber size (soleus type I fibers: mean fiber size in the immobilized hindlimb only 69% of that in the nonimmobilized hindlimb). Many of these changes could not be corrected by free remobilization, whereas low- and high-intensity treadmill running clearly restored the changes toward control levels, the effect being most complete in the high-intensity running group. Collectively, these findings indicate that immobilization-induced pathological structural and histochemical alterations in rat calf muscles are, to a great extent, reversible phenomena if remobilization is intensified by physical training. In this respect, high-intensity exercise seems more beneficial than low-intensity exercise.
大鼠后肢悬吊过程中比目鱼肌纤维成分的变化。
DOI：
10.1152/jappl.1988.65.3.1191
发表时间：
1988
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Templeton,GH;Sweeney,HL;Timson,BF;Padalino,M;Dudenhoeffer,GA
通讯作者：
Dudenhoeffer,GA
影响因子：
3.3
作者：
ARMSTRONG, RB;OGILVIE, RW;SCHWANE, JA
通讯作者：
SCHWANE, JA