Interactions of the cell-wall glycopolymers of lactic acid bacteria with their bacteriophages.
Interactions of the cell-wall glycopolymers of lactic acid bacteria with their bacteriophages.
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DOI：
10.3389/fmicb.2014.00236
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发表时间：
2014
影响因子：
5.2
通讯作者：
Chapot-Chartier MP
中科院分区：
文献类型：
--
作者：
Chapot-Chartier MP
乳酸菌是一种革兰氏阳性菌，广泛用于生产发酵食品，特别是奶酪和酸奶。多年来，发酵过程中的噬菌体感染一直是一个主要的工业问题，并激发了许多研究工作。更好地了解噬菌体与宿主细菌相互作用的分子机制是开发有效的抗感染策略所必需的。细菌细胞壁在这些相互作用中起着关键作用。首先，噬菌体必须通过与细胞壁成分受体的特定相互作用吸附在细菌表面。下一步，噬菌体必须克服细胞壁肽聚糖（PG）构成的屏障，将DNA注入细菌细胞内。同样在感染周期结束时，噬菌体合成能够水解PG和裂解细菌细胞以释放噬菌体后代的内溶酶。在过去的十年中，随着基因组学和细胞壁成分结构分析的发展，在几种模型LAB中，对其结构和功能的了解取得了相当大的进展。在这里，我们描述了目前对最具特征的乳酸菌细胞壁糖共聚物结构的了解，强调了它们的结构变化，并介绍了它们在感染周期的不同步骤中在细菌-噬菌体特异性相互作用中的作用的现有数据。
Lactic acid bacteria (LAB) are Gram positive bacteria widely used in the production of fermented food in particular cheese and yoghurts. Bacteriophage infections during fermentation processes have been for many years a major industrial concern and have stimulated numerous research efforts. Better understanding of the molecular mechanisms of bacteriophage interactions with their host bacteria is required for the development of efficient strategies to fight against infections. The bacterial cell wall plays key roles in these interactions. First, bacteriophages must adsorb at the bacterial surface through specific interactions with receptors that are cell wall components. At next step, phages must overcome the barrier constituted by cell wall peptidoglycan (PG) to inject DNA inside bacterial cell. Also at the end of the infection cycle, phages synthesize endolysins able to hydrolyze PG and lyse bacterial cells to release phage progeny. In the last decade, concomitant development of genomics and structural analysis of cell wall components allowed considerable advances in the knowledge of their structure and function in several model LAB. Here, we describe the present knowledge on the structure of the cell wall glycopolymers of the best characterized LAB emphasizing their structural variations and we present the available data regarding their role in bacteria-phage specific interactions at the different steps of the infection cycle.
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影响因子：
3.7
作者：
Claes IJ;Schoofs G;Regulski K;Courtin P;Chapot-Chartier MP;Rolain T;Hols P;von Ossowski I;Reunanen J;de Vos WM;Palva A;Vanderleyden J;De Keersmaecker SC;Lebeer S
通讯作者：
Lebeer S
影响因子：
6.4
作者：
Claes IJ;Segers ME;Verhoeven TL;Dusselier M;Sels BF;De Keersmaecker SC;Vanderleyden J;Lebeer S
通讯作者：
Lebeer S
影响因子：
6.4
作者：
Garneau JE;Moineau S
通讯作者：
Moineau S
DOI：
10.1073/pnas.1301336110
发表时间：
2013-04-09
影响因子：
11.1
作者：
Desmyter, Aline;Farenc, Carine;Cambillau, Christian
通讯作者：
Cambillau, Christian
影响因子：
4.8
作者：
Frankel, Matthew B.;Schneewind, Olaf
通讯作者：
Schneewind, Olaf