Developmental pathways of myeloid-derived suppressor cells in neoplasia.
Developmental pathways of myeloid-derived suppressor cells in neoplasia.
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肿瘤中髓样衍生的抑制细胞的发育途径。
DOI：
10.1016/j.cellimm.2020.104261
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发表时间：
2021-03
影响因子：
4.3
通讯作者：
Abrams SI
中科院分区：
文献类型：
--
作者：
Abrams SI
免疫疗法已成为抗击癌症的主要武器。几十年的开创性工作导致了推动适应性免疫的创新方法的发现，这一点达到了顶峰。值得注意的是，T细胞上免疫检查点抑制受体的发现，以及随后针对这些受体的单抗的发展，称为免疫检查点抑制物(ICIS)。使用ICIS阻断这些受体会导致持续的效应器功能，这已经转化为多种人类癌症类型的增强的抗肿瘤反应。然而，这些治疗对部分患者有效，这意味着限制治疗潜力的重大障碍。虽然许多机制可能会阻碍免疫治疗的效力，但一个突出的机制是髓系来源的抑制细胞(MDSCs)的产生。MDSCs包括单核细胞和粒细胞类型，并介导促肿瘤和免疫抑制活性。在这里，我们总结了MDSCs在癌症中产生的几种途径，为识别独特的联合治疗干预提供了一个概念框架。
Immunotherapy has become a major weapon against the war on cancer. This has culminated from decades of seminal work that led to the discovery of innovative approaches to propel adaptive immunity. Notably, was the discovery of immune checkpoint inhibitory receptors on T cells, and the subsequent development of monoclonal antibodies that target those receptors, known as immune checkpoint inhibitors (ICIs). Blocking those receptors using ICIs leads to sustained effector function, which has translated to enhanced antitumor responses across multiple human cancer types. However, these treatments are effective in subsets of patients, implicating significant barriers limiting therapeutic potential. While numerous mechanisms may hinder immunotherapy potency, one prominent mechanism is the production of myeloid-derived suppressor cells (MDSCs). MDSCs comprise monocytic and granulocytic cell types and mediate pro-tumorigenic and immune suppressive activities. Here, we summarize several pathways by which MDSCs arise in cancer, providing a conceptual framework for identifying unique combination therapeutic interventions.
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DOI：
10.1084/jem.20150950
发表时间：
2016-05-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
D'Amico L;Mahajan S;Capietto AH;Yang Z;Zamani A;Ricci B;Bumpass DB;Meyer M;Su X;Wang-Gillam A;Weilbaecher K;Stewart SA;DeNardo DG;Faccio R
通讯作者：
Faccio R
影响因子：
20.3
作者：
Faber, Joerg;Krivtsov, Andrei V.;Armstrong, Scott A.
通讯作者：
Armstrong, Scott A.
影响因子：
7.4
作者：
Grützner E;Stirner R;Arenz L;Athanasoulia AP;Schrödl K;Berking C;Bogner JR;Draenert R
通讯作者：
Draenert R
DOI：
10.1084/jem.20130281
发表时间：
2013-10-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Capietto AH;Kim S;Sanford DE;Linehan DC;Hikida M;Kumosaki T;Novack DV;Faccio R
通讯作者：
Faccio R
影响因子：
16.6
作者：
Bronte V;Brandau S;Chen SH;Colombo MP;Frey AB;Greten TF;Mandruzzato S;Murray PJ;Ochoa A;Ostrand-Rosenberg S;Rodriguez PC;Sica A;Umansky V;Vonderheide RH;Gabrilovich DI
通讯作者：
Gabrilovich DI