Oral administration of apigenin inhibits metastasis through AKT/P70S6K1/MMP-9 pathway in orthotopic ovarian tumor model.
Oral administration of apigenin inhibits metastasis through AKT/P70S6K1/MMP-9 pathway in orthotopic ovarian tumor model.
复制标题
口服芹菜素通过 AKT/P70S6K1/MMP-9 通路抑制原位卵巢肿瘤模型的转移
DOI：
10.3390/ijms13067271
复制
发表时间：
2012
影响因子：
5.6
通讯作者：
Jiang BH
中科院分区：
文献类型：
--
作者：
He J;Xu Q;Wang M;Li C;Qian X;Shi Z;Liu LZ;Jiang BH
芹菜素是一种常见于日常饮食中的黄酮类化合物，以其潜在的抗肿瘤特性而闻名。然而，口服芹菜素对肿瘤生长和转移的影响尚不清楚。在本研究中，我们建立了裸鼠卵巢原位肿瘤模型，以检验芹菜素口服的效果，并在动物肿瘤模型中显示了芹菜素抑制癌细胞微转移的作用。为了了解芹菜素抑制肿瘤转移的机制，我们发现与对照组相比，芹菜素显著抑制了肿瘤组织中基质金属蛋白酶-9的表达以及p-AKT和p-p70S6K1的水平。我们进一步证明了芹菜素通过AKT/p70S6K1途径下调基质金属蛋白酶-9的表达。这些发现有助于解决公众共同感兴趣的问题，即口服摄取类黄酮是否有效预防癌症。在原位卵巢肿瘤模型上，我们的结果首次证明口服芹菜素可以通过表达基质金属蛋白酶-9来抑制肿瘤转移。
Apigenin, a flavonoid commonly present in the daily diet, is known for its potential anti-tumor properties. However, the effect of apigenin via oral administration on tumor growth and metastasis remains unknown. In this study we developed an orthotopic ovarian tumor model in nude mice to test the effect of apigenin oral administration, and showed that apigenin inhibited the micrometastasis of cancer cells in the animal tumor model. To understand the mechanism of apigenin in inhibiting metastasis, we found that apigenin greatly inhibited MMP-9 expression and p-AKT and p-p70S6K1 levels in the tumor tissues compared to the control group. We further demonstrated that the downregulation of MMP-9 by apigenin was mediated by the AKT/p70S6K1 pathway. These findings help to address the question with common interests to the public of whether oral uptake of flavonoids is effective in preventing cancer. Our results demonstrate for the first time that oral uptake of apigenin can inhibit tumor metastasis through MMP-9 expression using the orthotopic ovarian tumor model.
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DOI：
10.1073/pnas.76.5.2268
发表时间：
1979-01-01
影响因子：
11.1
作者：
LIOTTA, LA;ABE, S;MARTIN, GR
通讯作者：
MARTIN, GR
影响因子：
11.2
作者：
Shukla, Sanjeev;MacLennan, Gregory T.;Gupta, Sanjay
通讯作者：
Gupta, Sanjay
影响因子：
3.8
作者：
Lee, Wei-Jiunn;Chen, Wen-Kang;Tseng, Tsui-Hwa
通讯作者：
Tseng, Tsui-Hwa
影响因子：
4.8
作者：
Fang, J;Xia, C;Jiang, BH
通讯作者：
Jiang, BH
影响因子：
11.2
作者：
Chantrain, CF;Shimada, H;DeClerck, YA
通讯作者：
DeClerck, YA