Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons.
Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons.
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阿坎酸与乙醇和精胺对原代培养神经元 NMDA 受体的相互作用。
DOI：
10.1016/s0014-2999(00)00195-3
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发表时间：
2000
影响因子：
5
通讯作者：
Lovinger,DM
中科院分区：
文献类型：
--
作者：
Popp,RL;Lovinger,DM
The N-methyl-d-aspartate (NMDA) receptor has been implicated as a putative sight of action for acamprosate, a novel drug that reduces craving for alcohol. The purpose of this study was to assess the effect of acamprosate on the function of native NMDA receptors expressed in primary cultured striatal and cerebellar granule cells, as well as ethanol inhibition and spermine modulation of these receptors, using whole-cell patch-clamp electrophysiological techniques. Under all circumstances, acamprosate (0.1–300 μM) did not alter NMDA- or glutamate-induced currents. Acamprosate did not alter the inhibitory effects of ethanol (10–100 mM) on receptor function. In a subpopulation of striatal neurons, acamprosate did reverse the potentiating effects of spermine. These findings indicate that although acamprosate may modify polyamine modulation of the NMDA receptor, acamprosate alone does not alter receptor function nor does it modify ethanol inhibition of this receptor expressed in primary cultured striatal and cerebellar granule neurons.
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影响因子：
2.9
作者：
Hardy, PA;Chen, WB;Wilce, PA
通讯作者：
Wilce, PA
慢性乙醇治疗导致鸟氨酸脱羧酶活性增加：对多胺在乙醇依赖和戒断中的作用的影响。
DOI：
--
发表时间：
1998
期刊：
Alcoholism: Clinical and Experimental Research
影响因子：
--
作者：
M. Davidson;P. Wilce
通讯作者：
P. Wilce
DOI：
10.1111/j.1530-0277.1998.tb03871.x
发表时间：
1998
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
M. Naassila;S. Hammoumi;Elisabeth Legrand;Philippe Durbin;Martine Daoust
通讯作者：
Martine Daoust
阿坎酸（乙酰高牛磺酸钙）降低大鼠新皮质的突触后电位：可能涉及兴奋性氨基酸受体。
影响因子：
5
作者：
M. Zeise;Sergei Kasparov;Marco Capogna;W. Zieglgänsberger
通讯作者：
W. Zieglgänsberger
影响因子：
2.8
作者：
GEWISS, M;HEIDBREDER, C;DEWITTE, P
通讯作者：
DEWITTE, P