Shigella flexneri-HeLa cell interactions: a putative role for host cell protein kinases.
Shigella flexneri-HeLa cell interactions: a putative role for host cell protein kinases.
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福氏志贺氏菌-HeLa 细胞相互作用：宿主细胞蛋白激酶的假定作用。
DOI：
10.1111/j.1574-695x.1995.tb00016.x
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发表时间：
1995
影响因子：
--
通讯作者：
Niesel,DW
中科院分区：
文献类型：
--
作者：
Collaco,C;Dyer,RB;Doan,R;Herzog,NK;Niesel,DW
Epithelial cell invasion has been shown to be a prerequisite forShigella flexnerivirulence. Recently, we have documented the induction of transcription factor DNA binding activities as a result ofS. flexnerichallenge of HeLa cells. In this report, we show that HeLa cells challenged withS. flexneridisplay differences in phosphotyrosine-containing proteins. These changes are detected as early as 5 min post-challenge. Challenge with a noninvasiveipaBmutant strain resulted in the induction of a similar, but less intense, profile of phosphotyrosine-containing host cell proteins. Phosphotyrosine-containing proteins could be detected inS. flexneri, but were unique from those detected following HeLa cell challenge.S. flexneriinvasion of HeLa cell monolayers was reduced by treatment with protein kinase inhibitors. These data suggest a role for protein kinases in the initial response of host cells toS. flexneri.
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影响因子：
5.8
作者：
Long,RM;Moore,L
通讯作者：
Moore,L
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DOI：
--
发表时间：
1986
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Long,RM;Moore,L
通讯作者：
Moore,L
DOI：
10.1016/0006-291x(70)90786-2
发表时间：
1970-01-01
影响因子：
3.1
作者：
BURGOYNE, LA;WAGAR, MA;ATKINSON, MR
通讯作者：
ATKINSON, MR
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影响因子：
3.8
作者：
Lamb,RG;McCue,SB;Taylor,DR;McGuffin,MA
通讯作者：
McGuffin,MA
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影响因子：
10.4
作者：
通讯作者：
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