Expression and functions of transient receptor potential channels in liver diseases.
Expression and functions of transient receptor potential channels in liver diseases.
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瞬时受体电位通道在肝脏疾病中的表达及功能
DOI：
10.1016/j.apsb.2022.09.005
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发表时间：
2023-02
影响因子：
14.5
通讯作者：
Yu, Ye
中科院分区：
文献类型：
--
作者：
Wang, Wenhui;Liu, Pengyu;Zhang, Yalin;Yan, Li;Zhu, Michael X.;Wang, Jin;Yu, Ye
肝病是全球主要的卫生保健负担，包括对乙酰氨基酚过量、缺血再灌注或嗜肝病毒感染和慢性肝炎、酒精性肝病（ALD）、非酒精性脂肪性肝病（NAFLD）和肝细胞癌（HCC）引起的急性肝损伤。大多数肝脏疾病可实现的治疗策略仍然不足，突出了实质发病机制的重要性。瞬时受体电位（TRP）通道代表了调节肝脏基本生理过程的多种信号传导机制。肝脏疾病成为丰富我们对TRP通道认识的新探索领域也就不足为奇了。在这里，我们讨论了最近的研究结果，揭示了TRP在从各种损伤引起的早期肝细胞损伤到炎症、随后的纤维化和肝癌的基本病理过程中的功能。我们还从Gene expression Omnibus （GEO）或The Cancer Genome Atlas （TCGA）数据库和Kaplan-Meier Plotter估计的生存分析中探讨了TRPs在ALD、NAFLD和HCC患者肝脏组织中的表达水平。最后，我们讨论了药物靶向TRPs治疗肝脏疾病的治疗潜力和挑战。目的是更好地了解TRP通道在肝脏疾病中的意义，有助于发现新的治疗靶点和有效的药物。瞬时受体电位（Transient receptor potential， TRP）通道在不同病因患者的肝组织中表达多样，从早期肝细胞损伤到随后的病理过程起着复杂的作用。TRPs显示出治疗潜力，并可能提供治疗肝脏疾病的药理学靶点。
Liver diseases constitute a major healthcare burden globally, including acute hepatic injury resulted from acetaminophen overdose, ischemia–reperfusion or hepatotropic viral infection and chronic hepatitis, alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC). Attainable treatment strategies for most liver diseases remain inadequate, highlighting the importance of substantial pathogenesis. The transient receptor potential (TRP) channels represent a versatile signalling mechanism regulating fundamental physiological processes in the liver. It is not surprising that liver diseases become a newly explored field to enrich our knowledge of TRP channels. Here, we discuss recent findings revealing TRP functions across the fundamental pathological course from early hepatocellular injury caused by various insults, to inflammation, subsequent fibrosis and hepatoma. We also explore expression levels of TRPs in liver tissues of ALD, NAFLD and HCC patients from Gene Expression Omnibus (GEO) or The Cancer Genome Atlas (TCGA) database and survival analysis estimated by Kaplan–Meier Plotter. At last, we address the therapeutical potential and challenges by pharmacologically targeting TRPs to treat liver diseases. The aim is to provide a better understanding of the implications of TRP channels in liver diseases, contributing to the discovery of novel therapeutic targets and efficient drugs. Transient receptor potential (TRP) channels are variously expressed in in liver tissues of patients subjected to different etiological factors, which paly complex roles from early hepatocellular injury to subsequent pathological process. TRPs display therapeutical potential and may provide pharmacological targets to treat liver diseases.
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影响因子：
30.5
作者：
Bertin S;Aoki-Nonaka Y;de Jong PR;Nohara LL;Xu H;Stanwood SR;Srikanth S;Lee J;To K;Abramson L;Yu T;Han T;Touma R;Li X;González-Navajas JM;Herdman S;Corr M;Fu G;Dong H;Gwack Y;Franco A;Jefferies WA;Raz E
通讯作者：
Raz E
DOI：
10.3390/antiox10081243
发表时间：
2021-08-03
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Ali ES;Rychkov GY;Barritt GJ
通讯作者：
Barritt GJ
影响因子：
7.3
作者：
Fonfria, E;Marshall, ICB;McNulty, S
通讯作者：
McNulty, S
影响因子：
3.7
作者：
Chen, Qing-Zi;Zhou, Yu-Bo;Li, Jian-Hua
通讯作者：
Li, Jian-Hua
影响因子：
3.7
作者：
Chen WT;Lin GB;Lin SH;Lu CH;Hsieh CH;Ma BL;Chao CY
通讯作者：
Chao CY