Associations of sedentary time and physical activity with adverse health conditions: Outcome-wide analyses using isotemporal substitution model.
Associations of sedentary time and physical activity with adverse health conditions: Outcome-wide analyses using isotemporal substitution model.
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DOI：
10.1016/j.eclinm.2022.101424
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发表时间：
2022-06
影响因子：
15.1
通讯作者：
中科院分区：
文献类型：
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作为当今最常见的生活方式之一，久坐行为是许多健康状况的危险因素。为了为潜在的行为指南的制定提供信息，我们旨在评估用不同强度的体力活动代替久坐行为对 45 种常见非传染性疾病 (NCD) 风险的理论影响。英国生物银行共纳入了 360,047 名未患有 45 种常见非传染性疾病 (NCD) 的参与者（年龄 37-73 岁）。通过基线自我报告收集有关久坐时间（看电视、使用电脑和驾驶行为的总和）和体力活动（通过国际体力活动调查问卷测量）的信息。直到 2020 年，参与者根据 ICD-10 代码使用国家健康记录链接对 45 种非传染性疾病的诊断进行了随访。在调整潜在的混杂因素后，使用等时替代模型研究用轻度体力活动 (LPA)、中度体力活动 (MPA) 和剧烈体力活动 (VPA) 替代久坐时间。每天静坐时间 > 6 小时的参与者与每天静坐时间≤ 2 小时的参与者相比，45 种非传染性疾病中有 12 种 (26.7%) 的风险较高，包括缺血性心脏病、糖尿病、慢性阻塞性肺病、哮喘、慢性肾病、慢性肝病、甲状腺疾病、抑郁症、偏头痛、痛风、类风湿性关节炎和憩室病。理论上，用同等 LPA、MPA 和 VPA 取代久坐时间分别与 4、6 和 10 种非传染性疾病风险降低相关。在长时间久坐时间（> 6 小时/天）中，用同等 VPA 代替 1 小时/天久坐时间与 5 种非传染性疾病（糖尿病、抑郁症、慢性肝病、憩室病和睡眠障碍）的关联性更强，风险降低幅度更大，达 11%-31%。久坐时间与多种不利的健康状况相关，用任何与 LPA 和 MPA 等量的 VPA 代替久坐时间可能会降低更多类型的非传染性疾病的风险。国家自然科学基金委。
As one of the most common lifestyles today, sedentary behaviour is a risk factor for many health conditions. To inform potential behavioural guideline development, we aimed to estimate the theoretical effects of replacing sedentary behaviour with different intensity of physical activity on risks of 45 common non-communicable diseases (NCDs). A total of 360,047 participants (aged 37-73 years) in the UK Biobank free of the 45 common non-communicable diseases (NCDs) were included. Information on sedentary time (sum of television watching, computer using and driving behaviour) and physical activity (measured by International Physical Activity Questionnaire questionnaire) were collected by self-reported at baseline. Participants were followed up for 45 NCDs diagnosis according to the ICD-10 code using linkage to national health records until 2020. Isotemporal substitution models were used to investigate substituting sedentary time with light physical activity (LPA), moderate physical activity (MPA) and vigorous physical activity (VPA) after adjusting for potential confounders. Participants who reported > 6 h/day compared with ≤ 2 h/day sedentary time had higher risks of 12 (26.7%) of 45 NCDs, including ischemic heart disease, diabetes, chronic obstructive pulmonary disease, asthma, chronic kidney disease, chronic liver disease, thyroid disorder, depression, migraine, gout, rheumatoid arthritis and diverticular disease. Theoretically, replacing sedentary time with equivalent LPA, MPA and VPA was associated with risk reductions in 4, 6 and 10 types of NCDs, respectively. Among long sedentary time (> 6 h/day), replacing 1 h/day sedentary time with equivalent VPA showed stronger associations with 5 NCDs (diabetes, depression, chronic liver disease, diverticular disease and sleep disorder), with a larger risk reduction of 11%-31%. Sedentary time is associated with multiple adverse health conditions, replacing sedentary time with any equivalent amounts of VPA than LPA and MPA could be associated with risk reductions of more types of NCDs. National Natural Science Foundation of China.
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影响因子：
24
作者：
Chomistek, Andrea K.;Manson, JoAnn E.;Stefanick, Marcia L.;Lu, Bing;Sands-Lincoln, Megan;Going, Scott B.;Garcia, Lorena;Allison, Matthew A.;Sims, Stacy T.;LaMonte, Michael J.;Johnson, Karen C.;Eaton, Charles B.
通讯作者：
Eaton, Charles B.
影响因子：
6.3
作者：
Heron, Leonie;O'Neill, Ciaran;Tully, Mark A.
通讯作者：
Tully, Mark A.
影响因子：
37.8
作者：
Bellettiere, John;LaMonte, Michael J.;LaCroix, Andrea Z.
通讯作者：
LaCroix, Andrea Z.
影响因子：
8.9
作者：
Foster, Hamish M. E.;Ho, Frederick K.;Celis-Morales, Carlos A.
通讯作者：
Celis-Morales, Carlos A.
影响因子：
5.1
作者：
Hallgren, Mats;Thi-Thuy-Dung Nguyen;Ekblom-Bak, Elin
通讯作者：
Ekblom-Bak, Elin