Relationship of sedentary behavior and physical activity to incident cardiovascular disease: results from the Women's Health Initiative.
Relationship of sedentary behavior and physical activity to incident cardiovascular disease: results from the Women's Health Initiative.
复制标题
DOI：
10.1016/j.jacc.2013.03.031
复制
发表时间：
2013-06-11
影响因子：
24
通讯作者：
Eaton, Charles B.
中科院分区：
文献类型：
--
作者：
Chomistek, Andrea K.;Manson, JoAnn E.;Stefanick, Marcia L.;Lu, Bing;Sands-Lincoln, Megan;Going, Scott B.;Garcia, Lorena;Allison, Matthew A.;Sims, Stacy T.;LaMonte, Michael J.;Johnson, Karen C.;Eaton, Charles B.
目的是检查出现时间和体育锻炼的独立和联合关联，并有发生心血管疾病（CVD）的风险。
久坐的行为被认为是一种独特的结构，而不是缺乏休闲时间的体育锻炼，但是对这两个能量平衡组成部分之间的相互关系存在有限的数据。
前瞻性妇女健康计划观察性研究（n = 71,018）的参与者，年龄50-79岁，基线时没有CVD（1993–1998），提供了有关久坐行为的信息，该行为定义为每天坐着的时间，并且在基线和随访期间至2010年9月。首先调整了第一个CVD（冠心病或中风）事件。
与≤5小时/天相比，每天≥10小时，CVD风险增加（HR = 1.18，95％CI 1.09，1.29）在包括体育锻炼的多变量模型中也与更高的CVD风险有关（P）。 ，趋势<0.001）。 MET-HRS/WEAR）报告的坐姿≥10个小时，冠军和中风分别进行了检查。与年轻女性相比年龄较大。
在没有CVD病史的绝经后妇女中，长时间的坐姿与CVD风险增加，独立于休闲时间活动。
The aim was to examine the independent and joint associations of sitting time and physical activity with risk of incident cardiovascular disease (CVD). Sedentary behavior is recognized as a distinct construct beyond lack of leisure-time physical activity, but limited data exists on the interrelationship between these two components of energy balance. Participants in the prospective Women’s Health Initiative Observational Study (N = 71,018), aged 50–79 and free of CVD at baseline (1993–1998), provided information on sedentary behavior, defined as hours of sitting per day, and usual physical activity at baseline and during follow-up through September 2010. First CVD (coronary heart disease or stroke) events were centrally adjudicated. Sitting ≥ 10 hours/day compared to ≤ 5 hours/day was associated with increased CVD risk (HR=1.18, 95% CI 1.09, 1.29) in multivariable models including physical activity. Low physical activity was also associated with higher CVD risk (P, trend <0.001). When women were cross-classified by sitting time and physical activity (P, interaction = 0.94), CVD risk was highest in inactive women (≤1.7 MET-hrs/week) who also reported ≥10 hrs/day of sitting. Results were similar for CHD and stroke when examined separately. Associations between prolonged sitting and risk of CVD were stronger in overweight versus normal weight women and women aged 70 years and older compared to younger women. Prolonged sitting time was associated with increased CVD risk, independent of leisure-time physical activity, in postmenopausal women without a history of CVD. A combination of low physical activity and prolonged sitting augments CVD risk.
登录
查看更多内容
影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
影响因子：
16.2
作者：
Dunstan DW;Kingwell BA;Larsen R;Healy GN;Cerin E;Hamilton MT;Shaw JE;Bertovic DA;Zimmet PZ;Salmon J;Owen N
通讯作者：
Owen N
影响因子：
5.7
作者：
Owen N;Healy GN;Matthews CE;Dunstan DW
通讯作者：
Dunstan DW
影响因子：
7.7
作者：
Hamilton, Marc T.;Hamilton, Deborah G.;Zderic, Theodore W.
通讯作者：
Zderic, Theodore W.
影响因子：
7.1
作者：
Matthews, Charles E.;George, Stephanie M.;Schatzkin, Arthur
通讯作者：
Schatzkin, Arthur