Dermatitis Herpetiformis: A Cutaneous Gluten-Related Disorder with Possible Exception in Asian Patients
Dermatitis Herpetiformis: A Cutaneous Gluten-Related Disorder with Possible Exception in Asian Patients
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疱疹样皮炎：亚洲患者中可能存在例外的一种皮肤麸质相关疾病
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
O. Chika
中科院分区：
文献类型：
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作者：
O. Chika
疱疹样皮炎（DH）是一种自身免疫性大疱性疾病，其特征是在伸肌表面（如肘部、膝盖和臀部）出现强烈的慢性复发性水疱。在乳头顶端的中性粒细胞的收集是典型的组织病理学发现，和一个特征性的诊断特征是颗粒状免疫球蛋白A沉积在乳头真皮通过直接免疫荧光。DH与麸质敏感性肠病密切相关，被认为是麸质敏感性的皮肤表现;即，腹腔疾病的肠外表现无麸质饮食是DH患者的一线治疗方法，氨苯砜也有效。DH优先影响携带人类白细胞抗原（HLA）-DQ 2或HLA-DQ 8的白种人。主要的自身抗原是表皮转氨酶。本文综述了DH的确认特征和我们最近对日本DH患者的研究结果。
Dermatitis herpetiformis (DH) is an autoimmune bullous disease characterized by intensely pruritic, chronic, and recurrent vesicles on extensor surfaces such as the elbows, knees, and buttocks. The collection of neutrophils at the papillary tips is the typical histopathological finding, and a characteristic diagnostic feature is granular immunoglobulin A deposition in the papillary dermis by direct immunofluorescence. DH is closely associated with gluten sensitive enteropathy and is considered a cutaneous manifestation of gluten sensitivity; i.e., an extra-intestinal presentation of celiac disease. Gluten free diet is the first-line therapy for patients with DH and dapsone is also effective. DH preferentially affects Caucasians who carry human leukocyte antigen (HLA)-DQ2 or HLA-DQ8. The major autoantigen is epidermal transglutaminase. This review focuses on the confirmedfeatures of DH and our recent findings specific to DH in Japanese patients.
疱疹样皮炎和乳糜泻中的转谷氨酰胺酶自身抗体。
DOI：
10.1038/sj.jid.5701041
发表时间：
2008
期刊：
The Journal of investigative dermatology
影响因子：
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作者：
Marietta,EricV;Camilleri,MichaelJ;Castro,LuisA;Krause,PatriciaK;Pittelkow,MarkR;Murray,JosephA
通讯作者：
Murray,JosephA