Challenges in Biomaterial-Based Drug Delivery Approach for the Treatment of Neurodegenerative Diseases: Opportunities for Extracellular Vesicles.
Challenges in Biomaterial-Based Drug Delivery Approach for the Treatment of Neurodegenerative Diseases: Opportunities for Extracellular Vesicles.
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DOI：
10.3390/ijms22010138
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发表时间：
2020-12-25
影响因子：
5.6
通讯作者：
Kumar S
中科院分区：
文献类型：
--
作者：
Kumar A;Zhou L;Zhi K;Raji B;Pernell S;Tadrous E;Kodidela S;Nookala A;Kochat H;Kumar S
生物材料一直是众多研究的主题，以寻求潜在的治疗干预措施，以治疗各种各样的紊乱和疾病。人们对各种材料的物理和化学性质进行了探索，以开发具有独特优势的天然、合成或半合成材料，作为中枢神经系统（CNS）和非中枢神经系统疾病的药物传递系统。在这篇综述中，概述了常用的生物材料作为神经系统疾病的药物传递系统，平衡了与中枢神经系统药物传递相关的潜力和挑战。作为一种有效的药物传递系统，本文讨论了生物材料的期望特性，解决了诸如靶向药物传递、刺激反应性和体内药物控制释放等持续存在的挑战。最后，我们讨论了将细胞外囊泡（ev）作为药物递送系统的前景和局限性，以及它们在生物相容性、稳定性和靶向递送方面的应用，以及它们通过非侵入性方法递送治疗神经退行性疾病的能力。
Biomaterials have been the subject of numerous studies to pursue potential therapeutic interventions for a wide variety of disorders and diseases. The physical and chemical properties of various materials have been explored to develop natural, synthetic, or semi-synthetic materials with distinct advantages for use as drug delivery systems for the central nervous system (CNS) and non-CNS diseases. In this review, an overview of popular biomaterials as drug delivery systems for neurogenerative diseases is provided, balancing the potential and challenges associated with the CNS drug delivery. As an effective drug delivery system, desired properties of biomaterials are discussed, addressing the persistent challenges such as targeted drug delivery, stimuli responsiveness, and controlled drug release in vivo. Finally, we discuss the prospects and limitations of incorporating extracellular vesicles (EVs) as a drug delivery system and their use for biocompatible, stable, and targeted delivery with limited immunogenicity, as well as their ability to be delivered via a non-invasive approach for the treatment of neurodegenerative diseases.
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