AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.
AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.
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DOI：
10.1038/ncomms8176
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发表时间：
2015-05-27
影响因子：
16.6
通讯作者：
Pol, Albert
中科院分区：
文献类型：
--
作者：
Herms, Albert;Bosch, Marta;Reddy, Babu J. N.;Schieber, Nicole L.;Fajardo, Alba;Ruperez, Celia;Fernandez-Vidal, Andrea;Ferguson, Charles;Rentero, Carles;Tebar, Francesc;Enrich, Carlos;Parton, Robert G.;Gross, Steven P.;Pol, Albert
脂滴（ld）是细胞内的细胞器，为细胞过程提供脂肪酸（FAs），包括膜的合成和代谢能量的产生。虽然已知沿微管（MTs）双向移动，但LD运动的作用以及它是否促进与其他细胞器的相互作用尚不清楚。在这里，我们发现在营养饥饿期间，ld和线粒体从细胞中心转移到去酪氨酸MT上，采用分散分布。在细胞外围，ld -线粒体相互作用增加，ld有效地为线粒体β -氧化提供FAs。这种细胞适应需要激活能量传感器AMPK，在饥饿的情况下，AMPK同时增加LD运动，重组去酪氨酸mt网络并激活线粒体。总之，我们描述了一个专门的细胞网络的存在，该网络连接细胞能量状态和MT动力学，以协调营养缺乏时ld和线粒体的功能。脂滴（ld）为细胞过程提供脂肪酸，并在微管上双向移动。在这里，作者表明营养饥饿导致线粒体和LD沿去酪氨酸微管扩散到细胞周围，并以依赖ampk的方式增加LD与线粒体的相互作用。
Lipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of metabolic energy. While known to move bidirectionally along microtubules (MTs), the role of LD motion and whether it facilitates interaction with other organelles are unclear. Here we show that during nutrient starvation, LDs and mitochondria relocate on detyrosinated MT from the cell centre to adopt a dispersed distribution. In the cell periphery, LD–mitochondria interactions increase and LDs efficiently supply FAs for mitochondrial beta-oxidation. This cellular adaptation requires the activation of the energy sensor AMPK, which in response to starvation simultaneously increases LD motion, reorganizes the network of detyrosinated MTs and activates mitochondria. In conclusion, we describe the existence of a specialized cellular network connecting the cellular energetic status and MT dynamics to coordinate the functioning of LDs and mitochondria during nutrient scarcity. Lipid droplets (LDs) supply fatty acids to cellular processes and move bidirectionally on microtubules. Here the authors show that nutrient starvation causes dispersal of mitochondria and LD to the periphery of the cell along detyrosinated microtubules and increases LD–mitochondria interactions in an AMPK-dependent manner.
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影响因子：
21.3
作者：
通讯作者：
--
影响因子：
11.1
作者：
Krahmer, Natalie;Farese, Robert V., Jr.;Walther, Tobias C.
通讯作者：
Walther, Tobias C.
DOI：
10.1083/jcb.200911024
发表时间：
2010-08-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Friedman JR;Webster BM;Mastronarde DN;Verhey KJ;Voeltz GK
通讯作者：
Voeltz GK
AMP激活的蛋白激酶对ULK1（HATG1）的磷酸化将能量传感连接到线粒体。
DOI：
10.1126/science.1196371
发表时间：
2011-01-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Egan DF;Shackelford DB;Mihaylova MM;Gelino S;Kohnz RA;Mair W;Vasquez DS;Joshi A;Gwinn DM;Taylor R;Asara JM;Fitzpatrick J;Dillin A;Viollet B;Kundu M;Hansen M;Shaw RJ
通讯作者：
Shaw RJ
影响因子：
4
作者：
Aon MA;Bhatt N;Cortassa SC
通讯作者：
Cortassa SC