EGF receptor and its ligands, EGF and TGF-alpha, in developing and neoplastic human odontogenic tissues.
EGF receptor and its ligands, EGF and TGF-alpha, in developing and neoplastic human odontogenic tissues.
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EGF 受体及其配体，EGF 和 TGF-α，在发育中和肿瘤性人类牙源组织中。
DOI：
10.1387/ijdb.8292533
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
P. Miettinen
中科院分区：
文献类型：
--
作者：
K. Heikinheimo;R. Voutilainen;R. Happonen;P. Miettinen
表皮生长因子（EGF）和转化生长因子-α（TGF-alpha）通过EGF受体（EGF-R）调节细胞增殖和功能成熟。它们在人类牙齿发育和牙源性肿瘤发生中的作用尚未被探索。我们研究了EGF，TGF-α和EGF-R在人胎牙（帽状期至早期硬组织形成）和各种牙源性肿瘤中的表达。EGF-R mRNA和免疫反应阳性细胞主要位于牙源性上皮。EGF-R的表达在牙齿发育的不同阶段具有时空差异。EGF和TGF-α mRNA的检测仅在胎儿牙齿的逆转录聚合酶链反应（RT-PCR）。然而，EGF和TGF-α免疫反应细胞被证明在牙胚的上皮细胞，这表明肽部分来自非牙源性来源。在牙源性肿瘤中，EGF-R mRNA和免疫反应仅限于肿瘤上皮。在牙源性上皮、上皮-外胚间充质和外胚间充质来源的肿瘤中检测到TGF-α转录本，但未检测到EGF转录本。结论：EGF-R的表达在人牙胚发育过程中受到发育调控。此外，牙源性上皮是牙齿发育过程中EGF和TGF-α的主要靶组织。TGF-α及其受体也可能参与牙源性肿瘤的发生。
Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) regulate cell proliferation and functional maturation through the EGF receptor (EGF-R). Their roles in human tooth development and odontogenic tumorigenesis have not been explored. We studied the expression of EGF, TGF-alpha and EGF-R in human fetal teeth (cap stage to early hard tissue formation) and various odontogenic tumors. EGF-R mRNA and immunoreactive cells were mostly located in odontogenic epithelium. EGF-R expression was subject to temporospatial variation at different stages of tooth development. EGF and TGF-alpha mRNAs were detected in fetal teeth only by the reverse transcription polymerase chain reaction (RT-PCR). However, EGF and TGF-alpha immunoreactive cells were demonstrated in epithelial elements of tooth germ, suggesting that the peptides partially originate from non-odontogenic sources. In odontogenic tumors, EGF-R mRNA and immunoreactivity were confined to neoplastic epithelium. Transcripts for TGF-alpha but not for EGF were detected in tumors of odontogenic epithelial, epithelial-ectomesenchymal and ectomesenchymal origins. It is concluded that regulation of EGF-R expression is developmentally regulated in human odontogenesis. Furthermore, the odontogenic epithelium is the main target tissue for both EGF and TGF-alpha during tooth development. TGF-alpha and its receptor may also be involved in odontogenic tumorigenesis.
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小鼠胚胎发育过程中表皮生长因子前体在牙齿和肺中的定位。
影响因子：
2.7
作者：
Snead,ML;Luo,W;Oliver,P;Nakamura,M;Don-Wheeler,G;Bessem,C;Bell,GI;Rall,LB;Slavkin,HC
通讯作者：
Slavkin,HC
影响因子：
4.6
作者：
A. Vaahtokari;S. Vainio;I. Thesleff
通讯作者：
A. Vaahtokari;S. Vainio;I. Thesleff
影响因子：
4.6
作者：
K. Lyons;R. Pelton;B. Hogan
通讯作者：
K. Lyons;R. Pelton;B. Hogan
表皮生长因子 mRNA 在发育中的小鼠下颌突中的表达。
影响因子：
3
作者：
Kronmiller,JE;Upholt,WB;Kollar,EJ
通讯作者：
Kollar,EJ
内源性表皮生长因子调节胚胎小鼠磨牙形态发生的时间和模式。
DOI：
--
发表时间：
1992
期刊：
The International journal of developmental biology
影响因子：
--
作者：
Hu,CC;Sakakura,Y;Sasano,Y;Shum,L;BringasJr,P;Werb,Z;Slavkin,HC
通讯作者：
Slavkin,HC