C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls.
C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls.
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DOI：
10.3389/fimmu.2018.02230
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发表时间：
2018
影响因子：
7.3
通讯作者：
Weickert TW
中科院分区：
文献类型：
--
作者：
Jacomb I;Stanton C;Vasudevan R;Powell H;O'Donnell M;Lenroot R;Bruggemann J;Balzan R;Galletly C;Liu D;Weickert CS;Weickert TW
越来越多的证据表明炎症在精神分裂症中的作用，但急性精神病外周炎症增加的稳定性以及外周炎症与皮质厚度（神经病理学程度的衡量标准）相关的程度尚不清楚。在独立样本中，我们评估了外周炎症标志物C反应蛋白（CRP），以确定以下程度：（1）CRP在急性精神病住院期间升高和稳定，（2）认知，日常功能和症状严重程度是慢性精神分裂症患者显示CRP升高的特征，（3）CRP水平预测皮质厚度。研究1评估了174/280例急性精神病患者的外周CRP（主要结局）和其他血液指标，而研究2评估了85/97例慢性精神分裂症患者和71/87例健康对照者的外周CRP、认知和皮质厚度（主要结局）、症状和日常功能。在急性精神病患者中，CRP和嗜中性粒细胞与淋巴细胞的比值相对于正常临界值（59.8%的患者CRP升高）显著升高，而正常临界值在入院后仍升高。43%的慢性精神分裂症患者的CRP显着升高，而对照组的这一比例为20%。CRP升高的患者表现出明显较差的工作记忆，CRP与额叶、颞叶和颞叶脑区的皮质厚度呈负相关。这项工作支持炎症在精神病中的作用，并建议使用外周标记物（例如，CRP）与诊断结合可用于识别具有更多皮质神经病理学和认知缺陷的患者。
There is increasing evidence for the role of inflammation in schizophrenia, yet the stability of increased peripheral inflammation in acute psychosis and the degree to which peripheral inflammation relates to cortical thickness, a measure of the degree of neuropathology, are unknown. In independent samples, we assessed the peripheral inflammation marker C-reactive protein (CRP) to determine the extent to which: (1) CRP was elevated and stable across admissions for acute psychosis, (2) cognition, daily function and symptom severity are characteristic of chronically ill patients with schizophrenia displaying elevated CRP, and (3) CRP levels predict cortical thickness. Study 1 assessed peripheral CRP (primary outcome) and other blood measures in 174/280 people with acute psychosis while Study 2 assessed peripheral CRP, cognition and cortical thickness (primary outcomes), symptoms, and daily function in 85/97 chronically ill patients with schizophrenia and 71/87 healthy controls. In acute psychosis, CRP and neutrophil-to-lymphocyte ratio were significantly elevated relative to a normal cutoff (with 59.8% of patients having elevated CRP) which remained elevated across admissions. CRP was significantly elevated in 43% of chronically ill patients with schizophrenia compared to 20% in controls. Elevated CRP patients displayed significantly worse working memory and CRP was inversely correlated with cortical thickness in frontal, insula, and temporal brain regions. This work supports the role of inflammation in psychotic illnesses and suggests that use of peripheral markers (e.g., CRP) in conjunction with diagnosis could be used to identify patients with more cortical neuropathology and cognitive deficits.
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影响因子：
11
作者：
Fernandes, B. S.;Steiner, J.;Berk, M.
通讯作者：
Berk, M.
影响因子：
17.7
作者：
Callicott, JH;Mattay, VS;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
4.2
作者：
Costello, E. Jane;Copeland, William E.;Angold, Adrian
通讯作者：
Angold, Adrian
影响因子：
9.3
作者：
Boerrigter D;Weickert TW;Lenroot R;O'Donnell M;Galletly C;Liu D;Burgess M;Cadiz R;Jacomb I;Catts VS;Fillman SG;Weickert CS
通讯作者：
Weickert CS
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y