Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome.

Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome.
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胆汁酸代谢失调与癌症恶病质相关:肝脏和肠道微生物组的作用

DOI:
10.1002/jcsm.12798
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发表时间:
2021-12
期刊:
Journal of cachexia, sarcopenia and muscle
影响因子:
--
通讯作者:
Zhang X
Zhang X
中科院分区:
其他
文献类型:
--
作者:
Feng L;Zhang W;Shen Q;Miao C;Chen L;Li Y;Gu X;Fan M;Ma Y;Wang H;Liu X;Zhang X

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癌症恶病质是一种多因素代谢综合征,其中胆汁酸(BA)代谢可能参与。本研究的目的是阐明肝脏和肠道微生物群对癌症恶病质中BA代谢紊乱的贡献,并检查使用诸如牛磺熊去氧胆酸(TUDCA)的药物靶向BA代谢用于癌症恶病质治疗的可能性。
Cancer cachexia is a multifactorial metabolic syndrome in which bile acid (BA) metabolism might be involved. The aim of the present study was to clarify the contribution of liver and gut microbiota to BA metabolism disturbance in cancer cachexia and to check the possibility of targeting BA metabolism using agents such as tauroursodeoxycholic acid (TUDCA) for cancer cachexia therapy.
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