Visual evoked potential abnormalities in dyslexic children.
Visual evoked potential abnormalities in dyslexic children.
复制标题
阅读障碍儿童的视觉诱发潜在异常。
作者：
A. Romani;Stefano Conte;R. Callieco;Roberto Bergamaschi;Maurizio Versino;G. Lanzi;C. Zambrino;Vittorio Cosi
发展性阅读障碍（阅读障碍）传统上被认为是由于语言技能受损。最近的心理物理学数据表明，阅读障碍可能与视觉知觉缺陷有关。一些视觉诱发电位（VEP）研究已经解决了这一假设，但他们的结果远非一致。我们提交了9名阅读障碍受试者和9名年龄和性别匹配的正常对照进行棋盘模式逆转vep。主要实验变量为：大（每度0.5个周期；cpd）和小（2 cpd）检查和两个反转频率（2.1 Hz和8 Hz）；在所有四种条件下，平均亮度和对比度（分别为60 cd/m2和50%）保持不变。在2 cpd时，瞬态VEP （2.1 Hz）参数在对照组和阅读障碍患者之间没有差异。在0.5 cpd时，阅读障碍患者的N70振幅显著减小，N70潜伏期显著缩短。对于两种刺激大小，失读症患者的基本频率（8hz）以及稳态vep的第二和第三次谐波的振幅都较小。判别分析正确地分类了每个主题。我们的数据证实了失读症患者存在感知缺陷的假设。这种异常与空间和时间刺激频率有关：当出现大的刺激时，或当刺激频率高时，就会出现这种异常。这些数据支持了阅读障碍中选择性大细胞功能障碍的假说。
Developmental reading disability (dyslexia) has traditionally been attributed to impaired linguistic skills. Recent psychophysical data suggest that dyslexia may be related to a visual perceptual deficit. A few visual evoked potential (VEP) studies have addressed this hypothesis, but their results are far from consistent. We submitted 9 dyslexic subjects and 9 age- and sex-matched normal controls to checkerboard pattern reversal VEPs. The main experimental variables were: large (0.5 cycles per degree; cpd) and small (2 cpd) checks and two reversal frequencies (2.1 Hz and 8 Hz); mean luminance and contrast (60 cd/m2 and 50%, respectively) were kept constant in all four conditions. Transient VEP (2.1 Hz) parameters did not differ between controls and dyslexics at 2 cpd. At 0.5 cpd, N70 amplitude was significantly smaller and N70 latency significantly shorter in dyslexics. Amplitudes for the fundamental frequency (8 Hz), as well as for the second and third harmonics of the steady-state VEPs were smaller in dyslexics for both stimulus sizes. A discriminant analysis correctly classified each subject. Our data confirm the hypothesis of a perceptual deficit in dyslexic subjects. The abnormalities are related to spatial and temporal stimulus frequencies: they appear when large stimuli are presented, or when the stimulation frequency is high. These data support the hypothesis of selective magnocellular dysfunction in dyslexia.
影响因子：
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作者：
DUARA, R;KUSHCH, A;LUBS, H
通讯作者：
LUBS, H