The innate immune response and type 2 diabetes: evidence that leptin is associated with a stress‐related (acute‐phase) reaction
The innate immune response and type 2 diabetes: evidence that leptin is associated with a stress‐related (acute‐phase) reaction
复制标题
先天免疫反应和 2 型糖尿病：瘦素与应激相关（急性期）反应相关的证据
作者：
J. Pickup;G. Chusney;M. Mattock
瘦素由脂肪组织产生，控制食物摄入和体重。尽管血液中瘦素的水平反映了能量储存，但细胞因子也会刺激脂肪产生瘦素。因为我们提出 2 型糖尿病与细胞因子介导的急性期或应激反应（先天免疫系统的一部分）相关，所以我们寻找证据表明 2 型糖尿病中瘦素增加部分是作为应激反应，与肥胖和性别无关。
Leptin is produced by adipose tissue and controls food intake and body weight. Although blood levels of leptin reflect energy stores, cytokines also stimulate leptin production from fat. Because we have proposed that type 2 diabetes mellitus is associated with a cytokine‐mediated acute‐phase or stress response, part of the innate immune system, we sought evidence that leptin is increased in type 2 diabetes partly as a stress response, independently of obesity and sex.
影响因子：
158.5
作者：
Considine, RV;Sinha, MK;Caro, JF
通讯作者：
Caro, JF
影响因子：
15.9
作者：
Grunfeld, C;Zhao, C;Feingold, KR
通讯作者：
Feingold, KR