Human Placenta Blood Flow During Early Gestation With Pseudocontinuous Arterial Spin Labeling MRI.
Human Placenta Blood Flow During Early Gestation With Pseudocontinuous Arterial Spin Labeling MRI.
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DOI：
10.1002/jmri.26944
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发表时间：
2020-04
期刊：
影响因子：
--
通讯作者：
Sung K
中科院分区：
文献类型：
--
作者：
Liu D;Shao X;Danyalov A;Chanlaw T;Masamed R;Wang DJJ;Janzen C;Devaskar SU;Sung K
胎盘血流的无创测量是预测缺血性胎盘（IPD）的主要技术挑战。伪连续动脉自旋标记（pCASL）磁共振成像（MRI）近期显示出有应用前景，但在预测IPD后续发展方面的潜在价值尚不明确。
从pCASL MRI的纵向测量中得出整体和局部胎盘血流参数，并评估灌注相关参数与IPD之间的关联。
前瞻性研究。
从前瞻性招募的118名受试者中，84名女性完成了两次pCASL MRI扫描（第一次在14 - 18周，第二次在19 - 24周）。共有69名受试者被纳入分析，其中15名受试者发生了IPD。
3T/T2加权半傅里叶单次激发快速自旋回波（HASTE）和pCASL。
得出胎盘的四个灌注相关参数：胎盘体积、胎盘血流量（PBF）、高胎盘血流量（hPBF）和相对高胎盘血流量。在将这些参数根据妊娠第16周和第20周进行标准化后，对参数的纵向变化及其与IPD的关联进行了检测。
使用配对威尔科克森检验对受试者内两个孕周进行比较，使用非配对威尔科克森检验对正常组和IPD组进行比较。
对于正常受试者，第一次和第二次MRI扫描之间在体积（156.6立方厘米对269.7立方厘米，P < 0.001）和PBF（104.9毫升/100克/分钟对111.3毫升/100克/分钟，P = 0.02）上的差异具有统计学意义，表明随着孕周增加，孕期胎盘体积和血流量增加。在检测的参数中，在16周时，正常受试者和IPD受试者之间的差异在hPBF（278.1毫升/100克/分钟对180.7毫升/100克/分钟，P < 0.001）和相对hPBF（259.1%对183.2%，P < 0.001）上最为显著。
在妊娠14 - 18周时，IPD的高灌注相关影像参数较正常妊娠显著降低。
Noninvasive measurement of placental blood flow is the major technical challenge for predicting ischemic placenta (IPD). Pseudocontinuous arterial spin labeling (pCASL) MRI was recently shown to be promising, but the potential value in predicting the subsequence development of IPD is not known. To derive global and regional placental blood flow parameters from longitudinal measurements of pCASL MRI and to assess the associations between perfusion-related parameters and IPD. Prospective. Eighty-four women completed two pCASL MRI scans (first; 14–18 weeks and second; 19–24 weeks) from prospectively recruited 118 subjects. A total of 69 subjects were included for the analysis, of which 15 subjects developed IPD. 3T/T2-weighted half-Fourier single-shot turbo spin-echo (HASTE) and pCASL. Four perfusion-related parameters in the placenta were derived: placenta volume, placental blood flow (PBF), high PBF (hPBF), and relative hPBF. The longitudinal changes of the parameters and their association with IPD were tested after being normalizing to the 16th and 20th weeks of gestation. Comparisons between two gestational ages within subjects were performed using the paired Wilcoxon tests, and comparisons between normal and IPD groups were performed using the unpaired Wilcoxon tests. The difference between the first and second MRI scans was statistically significant for volume (156.6 cm3 vs. 269.7 cm3, P < 0.001) and PBF (104.9 ml/100g/min vs. 111.3 ml/100g/min, P = 0.02) for normal subjects, indicating an increase in pregnancy with advancing gestation. Of the parameters tested, the difference between the normal and IPD subjects was most pronounced in hPBF (278.1 ml/100g/min vs. 180.7 ml/100g/min, P < 0.001) and relative hPBF (259.1% vs. 183.2%, P < 0.001) at 16 weeks. The high perfusion-related image parameters for IPD were significantly decreased from normal pregnancy at 14–18 weeks of gestation.
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影响因子：
3.3
作者：
McMaster, MT;Zhou, Y;Fisher, SJ
通讯作者：
Fisher, SJ
DOI：
10.1186/1477-7827-2-53
发表时间：
2004-07-05
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Fisher, Susan J
通讯作者：
Fisher, Susan J
影响因子：
7.2
作者：
通讯作者：
--
影响因子：
4
作者：
Norwitz, Errol R
通讯作者：
Norwitz, Errol R
影响因子：
2.1
作者：
Langhoff, Lasse;Gronbeck, Lene;Vejlstrup, Niels
通讯作者：
Vejlstrup, Niels