The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury.
The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury.
复制标题
髓源性抑制细胞在刀豆蛋白 A 诱导的肝损伤中的保护作用。
DOI：
10.1007/s13238-014-0069-5
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发表时间：
2014-09
期刊：
影响因子：
21.1
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Diao W;Jin F;Wang B;Zhang CY;Chen J;Zen K;Li L
T细胞介导的暴发性肝炎的发病机制尚不完全清楚。在这项研究中，我们研究了髓源性抑制细胞（MDSCs）是否可以通过抑制T细胞增殖来预防ConA （ConA）诱导的肝炎。我们观察到在ConA治疗的早期，小鼠脾脏和肝脏中MDSCs的频率增加，这表明MDSCs可能参与了小鼠对ConA介导的炎症的初始抵抗。亚群分析表明，cona诱导小鼠肝脏中以粒细胞型MDSCs为主。将骨髓来源的MDSCs过继转移到cona处理的小鼠体内，结果表明MDSCs迁移到肝脏和脾脏，并通过ROS途径抑制T细胞增殖。此外，免疫抑制剂糖皮质激素治疗也显著增加了小鼠MDSCs的频率。将MDSCs转移到调节性T细胞（Treg）缺失的小鼠中，表明MDSCs对cona诱导的肝炎的保护作用是不依赖Treg的。总之，我们的研究结果表明，MDSCs在T细胞介导的肝炎中具有直接的保护作用，通过过继性转移或糖皮质激素治疗增加MDSCs的频率代表了一种潜在的基于细胞的急性炎症性疾病治疗策略。
The mechanism underlying T cell-mediated fulminant hepatitis is not fully understood. In this study, we investigated whether myeloid derived suppressor cells (MDSCs) could prevent the concanavalin A (ConA)-induced hepatitis through suppressing T cell proliferation. We observed an increase in the frequencies of MDSCs in mouse spleen and liver at early stage of ConA treatment, implicating that the MDSCs might be involved in the initial resistance of mice against ConA-mediated inflammation. Subpopulation analysis showed that the MDSCs in liver of ConA-induced mice were mainly granulocytic MDSCs. Adoptive transfer of the bone marrow-derived MDSCs into ConA-treated mice showed that the MDSCs migrated into the liver and spleen where they suppressed T cell proliferation through ROS pathway. In addition, the frequencies of MDSCs in mice were also significantly increased by the treatment with immune suppressor glucocorticoids. Transfer of MDSCs into the regulatory T cell (Treg)-depleted mice showed that the protective effect of MDSCs on ConA-induced hepatitis is Treg-independent. In conclusion, our results demonstrate that MDSCs possess a direct protective role in T cell-mediated hepatitis, and increasing the frequency of MDSCs by either adoptive transfer or glucocorticoid treatment represents a potential cell-based therapeutic strategy for the acute inflammatory disease.
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影响因子：
4.4
作者：
Lee, Richard W. J.;Creed, Thomas J.;Dayan, Colin M.
通讯作者：
Dayan, Colin M.
影响因子：
5.6
作者：
Greten TF;Manns MP;Korangy F
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影响因子：
13.5
作者：
CZAJA, AJ;DAVIS, GL;TASWELL, HF
通讯作者：
TASWELL, HF
影响因子：
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作者：
Nagaraj, Srinivas;Gupta, Kapil;Gabrilovich, Dmitry I.
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癌症扩增的骨髓源性抑制细胞通过膜结合 TGF-β1 诱导 NK 细胞无反应。
影响因子：
4.4
作者：
Li, Hequan;Han, Yanmei;Cao, Xuetao
通讯作者：
Cao, Xuetao