Myeloid derived suppressor cells in human diseases.
Myeloid derived suppressor cells in human diseases.
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DOI：
10.1016/j.intimp.2011.01.003
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发表时间：
2011-07
影响因子：
5.6
通讯作者：
Korangy F
中科院分区：
文献类型：
--
作者：
Greten TF;Manns MP;Korangy F
骨髓源性抑制细胞（MDSC）是一种具有免疫抑制功能的异质性细胞群。MDSC在人类疾病中的可用数据有限。这些数据的解释是复杂的事实，不同的标志物已被用于分析人类MDSC亚型在各种临床设置。人MDSC为CD 11b+、CD 33+、HLA-DRneg/low，可分为粒细胞CD 14 −和单核细胞CD 14+亚型。白细胞介素4 R α、VEGFR、CD 15和CD 66 b被认为是人MDSC更特异的标志物，但这些标志物仅在某些MDSC亚群中发现。直到今天，人类MDSC的最佳标志物仍然是它们的抑制功能，这可以通过诱导调节性T细胞直接或间接实现。免疫抑制活性与MDSC的高辅酶I酶1和iNOS活性以及ROS产生相关。不仅在小鼠模型中，而且更重要的是在癌症患者中，不同的药物已被证明可以逆转MDSC的免疫抑制功能或直接靶向这些细胞。已显示用全反式视黄酸的全身治疗使人MDSC成熟并逆转其免疫抑制功能。或者，MDSC可以通过用多靶向受体酪氨酸激酶抑制剂舒尼替尼治疗来靶向。本文综述了近年来有关MDSC的研究进展。
Myeloid derived suppressor cells (MDSC) have been described as a heterogeneous cell population with potent immune suppressor function in mice. Limited data are available on MDSC in human diseases. Interpretation of these data is complicated by the fact that different markers have been used to analyze human MDSC subtypes in various clinical settings. Human MDSC are CD11b+, CD33+, HLA-DRneg/low and can be divided into granulocytic CD14− and monocytic CD14+ subtypes. Interleukin 4Rα, VEGFR, CD15 and CD66b have been suggested to be more specific markers for human MDSC, however these markers can only be found on some MDSC subsets. Until today the best marker for human MDSC remains their suppressor function, which can be either direct or indirect through the induction of regulatory T cells. Immune suppressor activity has been associated with high arginase 1 and iNOS activity as well as ROS production by MDSC. Not only in murine models, but even more importantly in patients with cancer, different drugs have been shown to either reverse the immune suppressor function of MDSC or directly target these cells. Systemic treatment with all-trans-retinoic acid has been shown to mature human MDSC and reverse their immune suppressor function. Alternatively, MDSC can be targeted by treatment with the multi-targeted receptor tyrosine kinase inhibitor sunitinib. In this review will provide a comprehensive summary of the recent literature on human MDSC.
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影响因子：
4.4
作者：
Almand, B;Clark, JI;Gabrilovich, DI
通讯作者：
Gabrilovich, DI
影响因子：
20.3
作者：
Highfill, Steven L.;Rodriguez, Paulo C.;Blazar, Bruce R.
通讯作者：
Blazar, Bruce R.
影响因子：
4.4
作者：
Ko, Hyun-Jeong;Lee, Jung-Mi;Kang, Chang-Yuil
通讯作者：
Kang, Chang-Yuil
DOI：
10.1084/jem.20062602
发表时间：
2007-06-11
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Delano MJ;Scumpia PO;Weinstein JS;Coco D;Nagaraj S;Kelly-Scumpia KM;O'Malley KA;Wynn JL;Antonenko S;Al-Quran SZ;Swan R;Chung CS;Atkinson MA;Ramphal R;Gabrilovich DI;Reeves WH;Ayala A;Phillips J;Laface D;Heyworth PG;Clare-Salzler M;Moldawer LL
通讯作者：
Moldawer LL
影响因子：
5.8
作者：
Lathers, DMR;Clark, JI;Young, MRI
通讯作者：
Young, MRI