The Roles of Non-coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives.

The Roles of Non-coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives.
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非编码 RNA 在毛囊发育和再生中的作用:现状和进一步展望

DOI:
10.3389/fcell.2021.720879
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发表时间:
2021
影响因子:
5.5
通讯作者:
Wang X
Wang X
中科院分区:
生物学2区
文献类型:
--
作者:
Yang M;Weng T;Zhang W;Zhang M;He X;Han C;Wang X

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脱发是一个常见的问题,几乎影响到每个年龄组,被认为是一个美容或精神原因的问题。脱发引起的毛囊(HF)和头发的损失损害了自尊,体温调节,触觉和紫外线的保护。解决这个问题的一个策略是HF再生。许多信号通路和分子参与了HF的形态和再生,如Wnt/β-catenin、Sonic hedgehog、骨形态发生蛋白和Notch。非编码RNA(ncRNA),特别是microRNA和长ncRNA,通过调节这些信号通路在HF的发展和再生中具有重要的调节作用。本文综述了ncRNA在HF再生中的现状和未来前景,并可能促进新的基于ncRNA的治疗策略。
Alopecia is a common problem that affects almost every age group and is considered to be an issue for cosmetic or psychiatric reasons. The loss of hair follicles (HFs) and hair caused by alopecia impairs self-esteem, thermoregulation, tactile sensation and protection from ultraviolet light. One strategy to solve this problem is HF regeneration. Many signalling pathways and molecules participate in the morphology and regeneration of HF, such as Wnt/β-catenin, Sonic hedgehog, bone morphogenetic protein and Notch. Non-coding RNAs (ncRNAs), especially microRNAs and long ncRNAs, have significant modulatory roles in HF development and regeneration via regulation of these signalling pathways. This review provides a comprehensive overview of the status and future prospects of ncRNAs in HF regeneration and could prompt novel ncRNA-based therapeutic strategies.
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发表时间: 2005-09-02
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