What is the optimal lipid emulsion for preventing intestinal failure-associated liver disease following parenteral feeding in a rat model of short-bowel syndrome?
What is the optimal lipid emulsion for preventing intestinal failure-associated liver disease following parenteral feeding in a rat model of short-bowel syndrome?
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在短肠综合征大鼠模型中，预防肠外喂养后肠衰竭相关肝病的最佳脂肪乳剂是什么？
DOI：
10.1007/s00383-020-04802-0
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发表时间：
2021-03
影响因子：
1.8
通讯作者：
Ieiri S
中科院分区：
文献类型：
--
作者：
Machigashira S;Kaji T;Onishi S;Yano K;Harumatsu T;Yamada K;Yamada W;Matsukubo M;Muto M;Ieiri S
复合脂肪乳剂（CLE）已被用于治疗肠衰竭相关性肝病（IFALD），以弥补大豆油脂肪乳剂（SOLE）或鱼油脂肪乳剂（FOLE）的缺点。然而，其管理的影响尚不清楚。我们使用短肠综合征大鼠模型评价了这些乳剂对IFALD的影响。我们对Sprague-Dawley大鼠进行颈静脉插管和90%小肠切除术，并将其分为四组：对照组（C组），常规饮食并静脉注射生理盐水;以及全肠外营养与SOLE（SOLE组），CLE（CLE组）或FOLE（FOLE组）共输注。组织学上，在SOLE和CLE组中观察到明显的肝脏脂肪变性，但FOLE组未观察到。FOLE组脂肪变性和气球样变的肝损伤程度明显优于SOLE组（p < 0.05）。FOLE组肝脏TNF-α水平显著低于SOLE组（p < 0.05）。在任何组中均未观察到必需脂肪酸缺乏症（EFAD）。鱼油脂肪乳剂在没有EFAD的情况下减轻了肝脂肪变性，而CLE诱导了中度肝脂肪变性。CLE的给药需要仔细观察，以防止PN诱导的肝脂肪变性。
Composite lipid emulsion (CLE) has been used for intestinal failure-associated liver disease (IFALD) to compensate for the disadvantages of soybean oil lipid emulsion (SOLE) or fish oil lipid emulsion (FOLE). However, the influence of its administration is unclear. We evaluated the effects of these emulsions on IFALD using a rat model of the short-bowel syndrome. We performed jugular vein catheterization and 90% small bowel resection in Sprague–Dawley rats and divided them into four groups: control (C group), regular chow with intravenous administration of saline; and total parenteral nutrition co-infused with SOLE (SOLE group), CLE (CLE group) or FOLE (FOLE group). Histologically, obvious hepatic steatosis was observed in the SOLE and CLE groups but not the FOLE group. The liver injury grade of the steatosis and ballooning in the FOLE group was significantly better than in the SOLE group (p < 0.05). The TNF-α levels in the liver in the FOLE group were significantly lower than in the SOLE group (p < 0.05). Essential fatty acid deficiency (EFAD) was not observed in any group. Fish oil lipid emulsion attenuated hepatic steatosis without EFAD, while CLE induced moderate hepatic steatosis. The administration of CLE requires careful observation to prevent PN-induced hepatic steatosis.
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影响因子：
3.4
作者：
Diamond, Ivan R.;Grant, Robert C.;Wales, Paul W.
通讯作者：
Wales, Paul W.
影响因子：
29.4
作者：
Kelly, DA
通讯作者：
Kelly, DA
DOI：
10.1016/j.plefa.2013.02.008
发表时间：
2013-09-01
影响因子：
3
作者：
Nandivada, P.;Cowan, E.;Puder, M.
通讯作者：
Puder, M.
肿瘤坏死因子-α的脂肪表达--在与肥胖相关的胰岛素抵抗中的直接作用
影响因子：
56.9
作者：
HOTAMISLIGIL, GS;SHARGILL, NS;SPIEGELMAN, BM
通讯作者：
SPIEGELMAN, BM
影响因子：
5.9
作者：
Plat, Jogchum;Baumgartner, Sabine;Mensink, Ronald P.
通讯作者：
Mensink, Ronald P.