Early life growth trajectories and future risk for overweight.
Early life growth trajectories and future risk for overweight.
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DOI：
10.1038/nutd.2012.32
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发表时间：
2013-02-04
影响因子：
6.1
通讯作者：
Fernald, L. C. H.
中科院分区：
文献类型：
--
作者：
Jones-Smith, J. C.;Neufeld, L. M.;Laraia, B.;Ramakrishnan, U.;Garcia-Guerra, A.;Fernald, L. C. H.
关键词：
标准方法发现，生命最初2年的快速生长是儿童后期超重的一个风险因素。我们的目的是使用一种非线性随机效应模型来检验生长速度（独立于同期的体型大小）是否与超重相关，该模型允许更精确的设定和估计。
来自墨西哥一个出生队列（n = 586）的纵向数据被用于使用平移和旋转叠加（SITAR）模型估计0 - 24个月期间体重指数（BMI）、身长和体重的生长轨迹。SITAR模型使用非线性随机效应模型来估计BMI、身长和体重的平均生长曲线，以及每个参与者在三个维度——体型大小、速度和峰值速度出现的时间——上偏离该曲线的情况。我们使用逻辑回归来估计7 - 9岁时的超重状况与0 - 24个月期间BMI、身长和体重轨迹的体型大小、速度和时间之间的关联。我们检验了速度和超重之间的任何关联是否因0 - 24个月期间的相对体型大小或出生体重而有所不同。
SITAR模型解释了0 - 24个月期间BMI（73%）、身高（86%）和体重（85%）的大部分变异。当单独分析时，0 - 24个月期间的相对BMI/身长/体重（体型大小）以及BMI/身长/体重速度都各自与儿童后期超重的几率增加有关。峰值速度出现时间的关联因人体测量指标而异。然而，在相互调整的模型中，只有相对BMI/身长/体重（体型大小）在统计学上仍然显著。我们没有发现证据表明速度和超重之间的任何关联因0 - 24个月期间的体型大小或出生体重而有所不同。
在相互调整之后，生命0 - 24个月期间的体型大小（而非出生时的体型大小），而不是速度或峰值速度出现的时间，与儿童后期的超重最为一致地相关。
Standard approaches have found that rapid growth during the first 2 years of life is a risk factor for overweight in later childhood. Our objective was to test whether growth velocity, independent of concurrent size, was associated with overweight using a nonlinear random-effects model that allows for enhanced specifications and estimations. Longitudinal data from a birth cohort in Mexico (n=586) were used to estimate growth trajectories over 0–24 months for body mass index (BMI), length and weight using the SuperImposition by Translation and Rotation (SITAR) models. The SITAR models use a nonlinear random-effects model to estimate an average growth curve for BMI, length and weight and each participant's deviation from this curve on three dimensions—size, velocity and timing of peak velocity. We used logistic regression to estimate the association between overweight status at 7–9 years and size, velocity and timing of BMI, length and weight trajectories during 0–24 months. We tested whether any association between velocity and overweight varied by relative size during 0–24 months or birth weight. SITAR models explained the majority of the variance in BMI (73%), height (86%) and weight (85%) between 0–24 months. When analyzed individually, relative BMI/length/weight (size) and BMI/length/weight velocity during 0–24 months were each associated with increased odds of overweight in late childhood. Associations for timing of peak velocity varied by anthropometric measure. However, in the mutually adjusted models, only relative BMI/length/weight (size) remained statistically significant. We found no evidence that any association between velocity and overweight varied by size during 0–24 months or birth weight. After mutual adjustment, size during 0–24 months of life (as opposed to birth size), but not velocity or timing of peak velocity, was most consistently associated with overweight in later childhood.
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影响因子：
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通讯作者：
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