Biomaterials to enhance antigen-specific T cell expansion for cancer immunotherapy.
Biomaterials to enhance antigen-specific T cell expansion for cancer immunotherapy.
复制标题
生物材料可增强抗原特异性T细胞扩张以进行癌症免疫疗法。
DOI：
10.1016/j.biomaterials.2020.120584
复制
发表时间：
2021-01
期刊：
影响因子：
14
通讯作者：
Schneck JP
中科院分区：
文献类型：
--
作者：
Isser A;Livingston NK;Schneck JP
T细胞通常被称为我们免疫系统的“制导导弹”，因为它们能够运输并积累在感染或疾病部位，以高特异性和敏感性破坏感染或突变的细胞，启动全身免疫反应，消除感染，并产生持久的记忆。因此，它们是一系列癌症免疫疗法的共同靶标。然而，扩增大量特异于每个患者独特肿瘤抗原的T细胞的无数挑战促使研究人员开发出替代的、更具可扩展性的方法。用于扩增抗原特异性T细胞的生物材料平台通过提供“现成的”但模块化的方法来定制T细胞应答的表型、功能和特异性，为大规模转化个性化免疫疗法提供了一条前进的道路。在这篇综述中，我们讨论了设计的考虑因素和在体外和体内技术的发展中取得的进展，用于激活抗原特异性T细胞，包括人工抗原呈递细胞，T细胞刺激支架，生物材料为基础的疫苗，和人工淋巴器官。这些平台作为癌症免疫治疗方案的一部分的最终转化取决于对T细胞生物学和细胞-材料相互作用的深入理解。
T cells are often referred to as the ‘guided missiles’ of our immune system because of their capacity to traffic to and accumulate at sites of infection or disease, destroy infected or mutated cells with high specificity and sensitivity, initiate systemic immune responses, sterilize infections, and produce long-lasting memory. As a result, they are a common target for a range of cancer immunotherapies. However, the myriad of challenges of expanding large numbers of T cells specific to each patient’s unique tumor antigens has led researchers to develop alternative, more scalable approaches. Biomaterial platforms for expansion of antigen-specific T cells offer a path forward towards broadscale translation of personalized immunotherapies by providing “off-the-shelf”, yet modular approaches to customize the phenotype, function, and specificity of T cell responses. In this review, we discuss design considerations and progress made in the development of ex vivo and in vivo technologies for activating antigen-specific T cells, including artificial antigen presenting cells, T cell stimulating scaffolds, biomaterials-based vaccines, and artificial lymphoid organs. Ultimate translation of these platforms as a part of cancer immunotherapy regimens hinges on an in-depth understanding of T cell biology and cell-material interactions.
登录
查看更多内容
T细胞共刺激和共抑制的分子机制。
DOI：
10.1038/nri3405
发表时间：
2013-04
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
30.5
作者：
Chang VT;Fernandes RA;Ganzinger KA;Lee SF;Siebold C;McColl J;Jönsson P;Palayret M;Harlos K;Coles CH;Jones EY;Lui Y;Huang E;Gilbert RJC;Klenerman D;Aricescu AR;Davis SJ
通讯作者：
Davis SJ
影响因子：
9.7
作者：
Andorko JI;Hess KL;Pineault KG;Jewell CM
通讯作者：
Jewell CM
DOI：
10.1083/jcb.201406120
发表时间：
2015-02-16
期刊：
The Journal of cell biology
影响因子：
--
作者：
Comrie WA;Li S;Boyle S;Burkhardt JK
通讯作者：
Burkhardt JK
影响因子：
56.9
作者：
Balint, S.;Muller, S.;Dustin, M. L.
通讯作者：
Dustin, M. L.