Changes in plasma progesterone concentrations around the time of the luteinizing hormone surge in women superovulated for in vitro fertilization.
Changes in plasma progesterone concentrations around the time of the luteinizing hormone surge in women superovulated for in vitro fertilization.
复制标题
体外受精超数排卵女性黄体生成素激增前后血浆黄体酮浓度的变化。
DOI：
10.1210/jcem-59-6-1075
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
R. Calabrese
中科院分区：
文献类型：
--
作者：
Alan O Trounson;R. Calabrese
本研究的目的是检查使用克罗米芬柠檬酸盐和人绝经期促性腺激素进行体外受精 (IVF) 超排卵的女性 LH 激增开始前后血浆孕酮 (P4) 的变化。人们认为，P4水平的变化与LH激增的发生密切相关，可能是IVF卵母细胞恢复时间的准确指标，并且过早的P4分泌可能会阻止胚胎置换后妊娠的建立。在 72 名女性 LH 激增之前 36 小时至之后 16 小时期间，在 0800、1400 和 2100 小时测定的血浆 P4 浓度显示出显着的昼夜变化，最低点出现在 0800 小时。分别有 51%、32% 和 17% 的患者在 0800、1400 和 2100 小时检测到 LH 激增。平均 P4 浓度的第一次显着增加与 1400 小时和 2100 小时 LH 激增的开始同时发生，但由于 P4 的日最低点在 0800 小时，平均 P4 水平的增加被推迟到 1400 小时，此时 LH 激增在 0800 小时开始。在 LH 激增开始前 1400 和 2100 小时，个别患者的 P4 浓度从 2 nmol/L 升高至 8 nmol/L 并不能阻止胚胎移植后妊娠的建立。随着成熟卵泡数量的增加，LH 激增之前和之后的 P4 浓度较高。我们得出的结论是，血浆 P4 浓度的变化可用于确定 IVF 的排卵时间或卵母细胞恢复时间，因为它们与 LH 激增的发生时间密切相关。
The purpose of the present study was to examine plasma progesterone (P4) changes around the time of the onset of the LH surge in women superovulated with clomiphene citrate and human Menopausal Gonadotrophin for in vitro fertilization (IVF). It was considered that changes in P4 levels which should be closely associated with the onset of the LH surge may be an accurate indicator for the time of oocyte recovery for IVF and that premature P4 secretion may prevent the establishment of pregnancy after embryo replacement. The plasma P4 concentrations determined at 0800, 1400, and 2100 h during the period 36 h before to 16 h after the onset of the LH surge in 72 women showed a significant diurnal variation with the nadir at 0800 h. The onset of the LH surge was detected in 51%, 32%, and 17% of patients at 0800, 1400, and 2100 h, respectively. The first significant increase in mean P4 concentrations was coincident with the onset of the LH surge at 1400 and 2100 h but because of the diurnal nadir of P4 at 0800 h, the increase in mean P4 levels was delayed until 1400 h when the LH surge began at 0800 h. Elevation of P4 concentrations from 2 to 8 nmol/liter in individual patients at 1400 and 2100 h before the onset of the LH surge did not prevent the establishment of pregnancy after embryo transfer. P4 concentrations before and after the onset of the LH surge were higher with increasing numbers of mature follicles. We conclude that changes in plasma P4 concentrations may be used to determine the time of ovulation or oocyte recovery for IVF because of their close association with the timing of the onset of the LH surge.
影响因子：
5.8
作者：
HOFF, JD;QUIGLEY, ME;YEN, SSC
通讯作者：
YEN, SSC