The complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis.
The complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis.
复制标题
DOI：
10.1007/s00259-013-2518-4
复制
发表时间：
2013-12
影响因子：
9.1
通讯作者：
Fayad, Zahi A.
中科院分区：
文献类型：
--
作者：
Calcagno, Claudia;Ramachandran, Sarayu;Izquierdo-Garcia, David;Mani, Venkatesh;Millon, Antoine;Rosenbaum, David;Tawakol, Ahmed;Woodward, Mark;Bucerius, Jan;Moshier, Erin;Godbold, James;Kallend, David;Farkouh, Michael E.;Fuster, Valentin;Rudd, James H. F.;Fayad, Zahi A.
易损动脉粥样硬化斑块的炎症和新生血管是严重临床事件的关键危险因素。动态对比增强磁共振成像（DCE-MRI）和18f -氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）是两种能够分别量化斑块新生血管和炎症浸润的非侵入性成像技术。然而，它们在确定斑块易感性方面的相互作用以及它们可能的重叠尚未得到彻底的研究。在这里，我们研究了40名冠心病（CHD）或同等冠心病患者颈动脉DCE-MRI和18F-FDG PET之间的关系，这些患者被招募为斑块试验（NCT00655473）的一个子研究。dal-PLAQUE试验是一项评估胆固醇酯转移蛋白调节剂dalcetrapib的多中心研究。受试者接受解剖MRI、DCE-MRI和18F-FDG PET检查。只有dal-斑块的基线成像和生物标志物数据（随机化前）被用作本亚研究的一部分。我们的主要目的是评估DCE-MRI和18F-FDG PET数据之间的关系。作为次要终点，我们评估了a) PET数据与全血管解剖MRI数据之间的关系，以及b) DCE-MRI与匹配解剖MRI数据之间的关系。使用混合线性模型估计所有相关性。我们发现DCE-MRI的几个灌注指标与PET的18F-FDG摄取呈显著的负相关。关于我们的次要终点，解剖MRI测量的斑块负荷与DCE-MRI的几个灌注指标与PET的18F-FDG摄取之间存在显著关系。解剖MRI发现斑块组成与DCEMRI或18F-FDG PET指标之间没有关系。在这项研究中，我们观察到PET测量的18F-FDG摄取炎症与DCE-MRI测量的斑块灌注之间存在显著的弱反比关系。我们的研究结果表明，在斑块发展的不同阶段，斑块炎症和微血管形成之间可能存在复杂的关系。在未来的临床实践中，18F-FDG PET和DCE-MRI在识别心血管事件高风险受试者方面可能具有互补作用。
Inflammation and neovascularization in vulnerable atherosclerotic plaques are key risk factors for severe clinical events. Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) are two non-invasive imaging techniques capable of quantifying plaque neovascularization and inflammatory infiltrate respectively. However, their mutual role in defining plaque vulnerability and their possible overlap has not been thoroughly investigated. Here, we study the relationship between DCE-MRI and 18F-FDG PET in the carotid arteries of 40 subjects with coronary heart disease (CHD) or CHD equivalent, recruited as a substudy of the dal-PLAQUE trial (NCT00655473). The dal-PLAQUE trial was a multicenter study that evaluated dalcetrapib, a cholesteryl ester transfer protein modulator. Subjects underwent anatomical MRI, DCE-MRI and 18F-FDG PET. Only baseline imaging and biomarkers data (before randomization) from dal-PLAQUE were used as part of this substudy. Our primary goal was to evaluate the relationship between DCE-MRI and 18F-FDG PET data. As secondary endpoints, we evaluated the relationship between a) PET data and whole vessel anatomical MRI data, and b) DCE-MRI and matching anatomical MRI data. All correlations were estimated using a mixed linear model. We found a significant inverse relationship between several perfusion indices by DCE-MRI and 18F-FDG uptake by PET. Regarding our secondary endpoints, there was a significant relationship between plaque burden measured by anatomical MRI with several perfusion indices by DCE-MRI and 18F-FDG uptake by PET. No relationship was found between plaque composition by anatomical MRI with DCEMRI or 18F-FDG PET metrics. In this study we observed a significant, weak inverse relationship between inflammation measured as 18F-FDG uptake by PET and plaque perfusion by DCE-MRI. Our findings suggest that there may be a complex relationship between plaque inflammation and microvascularization during the different stages of plaque development. 18F-FDG PET and DCE-MRI may have complementary roles in identifying subjects at high risk for cardiovascular events in future clinical practice.
登录
查看更多内容
影响因子：
4.4
作者：
Calcagno, Claudia;Vucic, Esad;Mani, Venkatesh;Goldschlager, Gregg;Fayad, Zahi A.
通讯作者：
Fayad, Zahi A.
影响因子：
4.8
作者：
Minchenko, A;Leshchinsky, I;Caro, J
通讯作者：
Caro, J
影响因子：
19.7
作者：
Kerwin, William S.;O'Brien, Kevin D.;Yuan, Chun
通讯作者：
Yuan, Chun
影响因子：
168.9
作者：
Fayad, Zahi A.;Mani, Venkatesh;Woodward, Mark;Kallend, David;Abt, Markus;Burgess, Tracy;Fuster, Valentin;Ballantyne, Christie M.;Stein, Evan A.;Tardif, Jean-Claude;Rudd, James H. F.;Farkouh, Michael E.;Tawakol, Ahmed
通讯作者：
Tawakol, Ahmed
影响因子：
4.8
作者：
Kawaguchi, T;Veech, RL;Uyeda, K
通讯作者：
Uyeda, K