Reproducibility of black blood dynamic contrast-enhanced magnetic resonance imaging in aortic plaques of atherosclerotic rabbits.
Reproducibility of black blood dynamic contrast-enhanced magnetic resonance imaging in aortic plaques of atherosclerotic rabbits.
复制标题
DOI：
10.1002/jmri.22225
复制
发表时间：
2010-07
影响因子：
4.4
通讯作者：
Fayad, Zahi A.
中科院分区：
文献类型：
--
作者：
Calcagno, Claudia;Vucic, Esad;Mani, Venkatesh;Goldschlager, Gregg;Fayad, Zahi A.
研究动脉粥样硬化兔黑血动态对比增强（DCE）磁共振成像（MRI）的短期可重复性，以评估该技术在治疗干预后作为斑块进展和/或消退可靠读数的潜力。在基线和24小时后在1.5T MRI系统上对动脉粥样硬化兔进行DCE-MRI成像。通过计算信号强度与时间曲线（AUC）下的面积来分析DCE-MRI图像。类内相关系数（ICCs）用于评价扫描间、观察者内和观察者间的可重复性。此外，还评估了重测变异系数（CoV）。统计分析显示了良好的观察者间、观察者内和观察者间的一致性。所有ICCs均大于0.75,P < 0.01，表明测量结果非常一致。实验结果显示了良好的扫描间和良好的观察者间和观察者间的可重复性，这表明DCE-MRI可用于临床前环境，作为动脉粥样硬化新治疗干预措施的读数。这项初步工作鼓励在临床环境中调查DCE-MRI的可重复性，在那里它可以用于监测高风险患者和纵向临床药物试验。
To investigate the short-term reproducibility of black-blood dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in atherosclerotic rabbits to evaluate the potential of this technique to be a reliable readout of plaque progression and/or regression upon therapeutic intervention. Atherosclerotic rabbits were imaged at baseline and 24 hours later with DCE-MRI on a 1.5T MRI system. DCE-MRI images were analyzed by calculating the area under the signal intensity versus time curve (AUC). Intraclass correlation coefficients (ICCs) were used to evaluate interscan, intraobserver, and interobserver reproducibility. In addition, the test–retest coefficient of variation (CoV) was evaluated. Statistical analyses showed excellent interscan, intraobserver, and interobserver agreement. All ICCs were greater than 0.75, P < 0.01 indicating excellent agreement between measurements. Experimental results show good interscan and excellent intra- and interobserver reproducibility, suggesting that DCE-MRI could be used in preclinical settings as a read-out for novel therapeutic interventions for atherosclerosis. This preliminary work encourages investigating the reproducibility of DCE-MRI also in clinical settings, where it could be used for monitoring high-risk patients and in longitudinal clinical drug trials.
登录
查看更多内容
DOI：
10.1038/ncpcardio1444
发表时间：
2009-03
期刊：
NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE
影响因子：
--
作者：
El Aidi, Hamza;Mani, Venkatesh;Weinshelbaum, Karen B.;Aguiar, Silvia H.;Taniguchi, Hiroaki;Postley, John E.;Samber, Daniel D.;Cohen, Emil I.;Stern, Jessica;van der Geest, Rob J.;Reiber, Johan H. C.;Woodward, Mark;Fuster, Valentin;Gidding, Samuel S.;Fayad, Zahi A.
通讯作者：
Fayad, Zahi A.
影响因子：
2.9
作者：
Galbraith, SM;Lodge, MA;Padhani, AR
通讯作者：
Padhani, AR
影响因子：
19.7
作者：
Kerwin, William S.;O'Brien, Kevin D.;Yuan, Chun
通讯作者：
Yuan, Chun
影响因子：
168.9
作者：
Lopez, Alan D.;Mathers, Colin D.;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
影响因子：
4.4
作者：
Roberts, C;Issa, B;Parker, GJM
通讯作者：
Parker, GJM