Sex differences in bladder cancer pathology and survival: analysis of a population-based cancer registry.
Sex differences in bladder cancer pathology and survival: analysis of a population-based cancer registry.
复制标题
DOI：
10.1002/cam4.379
复制
发表时间：
2015-03
期刊：
影响因子：
4
通讯作者：
Kobayashi, Yasuki
中科院分区：
文献类型：
--
作者：
Zaitsu, Masayoshi;Toyokawa, Satoshi;Tonooka, Akiko;Nakamura, Fumiaki;Takeuchi, Takumi;Homma, Yukio;Kobayashi, Yasuki
关键词：
膀胱癌病理和流行病学中的性别差异一直是近年来研究的热点。我们调查了日本膀胱癌的流行病学特征，并比较了男性和女性膀胱癌的病理和生存率。神奈川县大型癌症登记数据库中共确认了1954至2010年间确诊的13,184名原发性膀胱癌患者。在这个数据库中，我们使用调整了年龄和诊断周期的多元Logistic回归模型，比较了非尿路上皮癌(非UC)的优势比(OR)。我们还使用针对非UC、年龄和诊断期进行调整的Cox比例风险模型，比较了总体死亡和特定癌症死亡的风险比(HR)。女性非UC的比例显著高于男性(OR=2.14，95%可信区间：1.81~2.52)。此外，在调整UC或非UC因素后，女性患者的存活率显著低于男性患者(总体死亡的HR=1.15，95%CI：1.06-1.23；癌症特异性死亡的HR=61.39，95%CI：1.28-1.52)。日本膀胱癌的流行病学特征存在性别差异，女性患者较男性患者具有较差的病理分级和较差的存活率。
Sex differences in bladder cancer pathology and epidemiology have been the focus of recent research. We investigated the epidemiological characteristics and compared bladder cancer pathology and survival between men and women in Japan. A total of 13,184 patients with primary bladder cancer diagnosed from 1954 to 2010 were identified in a large-scale cancer registry database in Kanagawa Prefecture. Using this database, we compared the odds ratios (ORs) for nonurothelial carcinoma (non-UC) using a multiple logistic regression model adjusted for age and diagnosis periods. We also compared hazard ratios (HRs) for overall death and cancer-specific death using a Cox proportional hazards model adjusted for non-UC, age, and diagnosis period. The proportion of non-UC was significantly higher in female compared with male patients (OR = 2.14, 95% confidence interval [CI]: 1.81–2.52). Furthermore, survival was significantly poorer in female patients than in male patients after adjusting for UC or non-UC (HR for overall death = 1.15, 95% CI: 1.06–1.23; HR for cancer-specific death = 1.39, 95% CI: 1.28–1.52). Sex differences exist in the epidemiological characteristics of bladder cancer in Japan, with female patients having less favorable pathology and poorer survival compared with male patients.
登录
查看更多内容
影响因子：
6.2
作者：
Shen, Steven S.;Smith, Carolyn L.;Lerner, Seth P.
通讯作者：
Lerner, Seth P.
影响因子：
2.1
作者：
Boorjian, S;Ugras, S;Scherr, DS
通讯作者：
Scherr, DS
影响因子：
6.2
作者：
David, Kevin A.;Mallin, Katherine;Nanus, David M.
通讯作者：
Nanus, David M.
影响因子：
6.2
作者：
Scosyrev, Emil;Noyes, Katia;Messing, Edward
通讯作者：
Messing, Edward
DOI：
10.1111/j.1464-410x.1994.tb07122.x
发表时间：
1994-12-01
期刊：
BRITISH JOURNAL OF UROLOGY
影响因子：
--
作者：
DICKINSON, AJ;FOX, SB;HARRIS, AL
通讯作者：
HARRIS, AL