Evidence for two distinct c-src loci on human chromosomes 1 and 20
Evidence for two distinct c-src loci on human chromosomes 1 and 20
复制标题
人类 1 号和 20 号染色体上两个不同 c-src 位点的证据
作者：
M. L. Beau;C. Westbrook;M. Diaz;J. Rowley
最近，许多原癌基因被定位于染色体片段，这些片段是人类恶性疾病中特定重排的断点。此外，在恶性细胞中已经鉴定出几种原癌基因的重排形式。在一些情况下，原癌基因由于非随机染色体重排而发生改变2-4。一种尚未与人类肿瘤疾病相关的原癌基因是 c-src，它是劳斯肉瘤病毒 (RSV) 转化序列的细胞同源物。通过体细胞杂交，c-src已定位到20号染色体，但其精确位置尚未确定5。现在，我们通过使用克隆的人类 c-src 探针与人类有丝分裂染色体的原位杂交，绘制了该基因的图谱。我们在此报告，人类基因组包含两个与该癌基因的编码区具有高度同源性的位点，分别位于 Ip34-p36 和 20ql2-ql3。值得注意的是，这些染色体区域经常参与血液恶性疾病中观察到的结构重排6-8。
A number of proto-oncogenes have recently been localized to the chromosomal segments that are the breakpoints in the specific rearrangements noted in human malignant diseases1. Moreover, rearranged forms of several proto-oncogenes have been identified in malignant cells; in several instances, the proto-oncogene has undergone an alteration as a result of a nonrandom chromosomal rearrangement2–4. One proto-oncogene that has yet to be associated with human neoplastic disease is c-src, the cellular homologue of the transforming sequence of Rous sarcoma virus (RSV). By somatic cell hybridization, c-src has been mapped to chromosome 20, but its precise location was not determined5. We have now mapped this gene by using in situ hybridization of the cloned human c-src probe to human mitotic chromosomes. We report here that the human genome contains two loci with strong homology to the coding regions of this oncogene, at Ip34–p36 and 20ql2–ql3. It is noteworthy that these chromosomal regions are frequently involved in the structural rearrangements observed in haematological malignant diseases6–8.
与劳斯肉瘤病毒v-src同源的序列位于人类20号染色体上。
DOI：
10.1016/s0079-6603(08)60460-2
发表时间：
1983
期刊：
Progress in nucleic acid research and molecular biology
影响因子：
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作者：
Sakaguchi,AY;Naylor,SL;Shows,TB
通讯作者：
Shows,TB
第四届白血病染色体国际研讨会：急性非淋巴细胞白血病的前瞻性研究。
影响因子：
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作者：
通讯作者：
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影响因子：
56.9
作者：
SLAMON, DJ;DEKERNION, JB;CLINE, MJ
通讯作者：
CLINE, MJ