Reactive oxygen species in cancer.
Reactive oxygen species in cancer.
复制标题
DOI：
10.3109/10715761003667554
复制
发表时间：
2010-05
影响因子：
3.3
通讯作者：
Storz P
中科院分区：
文献类型：
--
作者：
Liou GY;Storz P
几乎在所有癌症中都检测到活性氧（ROS）的升高，它们促进了肿瘤发展和进展的许多方面。然而，肿瘤细胞也表达增加水平的抗氧化蛋白以从ROS中解毒，这表明癌细胞功能需要细胞内ROS水平的微妙平衡。此外，所产生的自由基、其产生的位置以及局部浓度对于癌症中ROS的细胞功能是重要的。新的治疗策略的挑战将是细胞内ROS信号传导的微调，以有效地剥夺细胞从ROS诱导的肿瘤促进事件，朝着倾斜的ROS诱导的凋亡信号传导的平衡。或者，治疗性抗氧化剂可以预防肿瘤发展的早期事件，其中ROS是重要的。然而，为了有效地靶向癌细胞，需要确定介导多种应激调节细胞功能的特定ROS传感信号通路。本文综述了ROS在肿瘤细胞内的产生、其解毒作用、细胞效应以及它们所利用的主要信号级联，并对其在治疗中的调节作用进行了展望。
Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers, where they promote many aspects of tumor development and progression. However, tumor cells also express increased levels of antioxidant proteins to detoxify from ROS, suggesting that a delicate balance of intracellular ROS levels is required for cancer cell function. Further, the radical generated, the location of its generation, as well as the local concentration is important for the cellular functions of ROS in cancer. A challenge for novel therapeutic strategies will be the fine tuning of intracellular ROS signaling to effectively deprive cells from ROS-induced tumor promoting events, towards tipping the balance to ROS-induced apoptotic signaling. Alternatively, therapeutic antioxidants may prevent early events in tumor development, where ROS are important. However, to effectively target cancer cells specific ROS-sensing signaling pathways that mediate the diverse stress-regulated cellular functions need to be identified. This review discusses the generation of ROS within tumor cells, their detoxification, their cellular effects, as well as the major signaling cascades they utilize, but also provides an outlook on their modulation in therapeutics.
登录
查看更多内容
影响因子：
6
作者：
Bonekamp, Nina A.;Voelkl, Alfred;Schrader, Michael
通讯作者：
Schrader, Michael
影响因子：
4.8
作者：
Bienert, Gerd P.;Moller, Anders L. B.;Jahn, Thomas P.
通讯作者：
Jahn, Thomas P.
影响因子：
11.2
作者：
Antosiewicz, Jedrzej;Herman-Antosiewicz, Anna;Singh, Shivendra V.
通讯作者：
Singh, Shivendra V.
DOI：
10.1073/pnas.0403621101
发表时间：
2004-07-06
影响因子：
11.1
作者：
Biswas, DK;Shi, Q;Iglehart, JD
通讯作者：
Iglehart, JD
影响因子：
4.8
作者：
Bae, YS;Sung, JY;Rhee, SG
通讯作者：
Rhee, SG