Smoking, central adiposity, and poor glycemic control increase risk of hearing impairment.
Smoking, central adiposity, and poor glycemic control increase risk of hearing impairment.
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DOI：
10.1111/jgs.13401
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发表时间：
2015-05
影响因子：
6.3
通讯作者：
Tweed TS
中科院分区：
文献类型：
--
作者：
Cruickshanks KJ;Nondahl DM;Dalton DS;Fischer ME;Klein BE;Klein R;Nieto FJ;Schubert CR;Tweed TS
确定吸烟、肥胖、糖尿病和其他心血管疾病（CVD）危险因素与15年听力损害（HI）发病率之间的关系。听力损失流行病学研究（EHLS）是一项基于人群的纵向队列研究（1993-95至2009-2010）。威斯康星州，比弗坝。比弗坝眼科研究（1988-90年;威斯康星州比弗坝居民，1987-88年年龄43-84岁）的参与者有资格参加EHLS。有1925名参与者在基线时听力正常。15-HI的年累积发生率（每只耳朵在0.5、1、2和4 kHz下听阈的纯音平均值（PTA）> 25分贝听力水平（dB HL））。通过问卷调查确定吸烟、运动和其他因素。测量血压、腰围、体重指数和糖化血红蛋白。87.2%（n=1678;平均基线年龄61岁）的患者进行了随访检查（≥1次）。15年累计HI发生率为56.8%。校正年龄和性别后，目前吸烟（风险比（HR）=1.31，p=0.048）、教育（<16岁; HR=1.35，p=0.01）、腰围（HR=1.08/10 cm，p=0.017）和糖尿病控制不良（HR=2.03，p=0.048）与HI风险增加相关。以前吸烟者和糖尿病控制较好的人的风险并没有增加。吸烟、中心性肥胖和控制不佳的糖尿病可预测HI事件。这些众所周知的CVD危险因素表明血管变化可能导致衰老中的HI。针对减少吸烟和肥胖的干预措施，以及改善糖尿病患者的血糖控制，可能有助于预防或延迟HI的发作。
To determine associations between smoking, adiposity, diabetes, and other cardiovascular disease (CVD) risk factors and the 15-yr incidence of hearing impairment (HI). The Epidemiology of Hearing Loss Study (EHLS) is a longitudinal population-based cohort study (1993–95 to 2009–2010). Beaver Dam, WI. Participants in the Beaver Dam Eye Study (1988–90; residents of Beaver Dam, WI ages 43–84 years in 1987–88) were eligible for the EHLS. There were 1925 participants with normal hearing at baseline. 15-year cumulative incidence of HI (pure-tone average (PTA) of hearing thresholds at 0.5, 1, 2 and 4 kHz > 25 decibels Hearing Level (dB HL) in either ear). Cigarette smoking, exercise, and other factors were ascertained by questionnaire. Blood pressure, waist circumference, body mass index and glycosylated hemoglobin were measured. Follow-up examinations (≥1) were obtained from 87.2% (n=1678; mean baseline age 61 years). The 15-year cumulative incidence of HI was 56.8%. Adjusting for age and sex, current smoking (Hazard Ratio (HR) =1.31, p=0.048), education (<16 yrs; HR=1.35, p=0.01), waist circumference (HR=1.08 per 10 cm, p=0.017), and poorly controlled diabetes (HR=2.03, p=0.048) were associated with increased risk of HI. Former smokers and people with better controlled diabetes were not at increased risk. Smoking, central adiposity and poorly controlled diabetes predicted incident HI. These well-known CVD risk factors, suggest vascular changes may contribute to HI in aging. Interventions targeting reductions in smoking and adiposity, and improved glycemic control in people with diabetes, may help to prevent or delay the onset of HI.
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影响因子：
3.9
作者：
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通讯作者：
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