Monomeric C-reactive protein level is associated with osteoarthritis.
Monomeric C-reactive protein level is associated with osteoarthritis.
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DOI：
10.3892/etm.2022.11206
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发表时间：
2022-04
影响因子：
2.7
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Liang Y;Xu K;Liu W;Liu X;Yuan P;Xu P;Li H
骨关节炎（OA）是一种以关节软骨退行性变和继发性骨质增生为特征的慢性关节疾病。C反应蛋白（CRP）是一种急性时相蛋白，广泛用作炎症标志物。在急性期OA患者中通常观察到CRP血浆水平升高。目前的证据表明，CRP解离成单体形式（mCRP）是炎症部位的主要功能构象。然而，目前尚不清楚mCRP是否与OA相关，以及mCRP是否可用作其发病机制的生物标志物。采用ELISA法检测CRP、mCRP及抗mCRP自身抗体的浓度。比较正常人和OA患者血浆CRP、mCRP及抗mCRP自身抗体水平。结果显示，血浆mCRP与OA密切相关，而mCRP自身抗体与OA的相关性很小。此外，确定Kelling-Lawrence（KL）4级患者的血浆mCRP水平显著高于KL 3级患者。因此，本研究揭示了血浆mCRP水平与OA相关，可直接反映患者的疾病程度。因此，mCRP可能是一个潜在的指标，可用于监测疾病的活动性和评估OA治疗的效果。
Osteoarthritis (OA) is a chronic joint disease characterized by articular cartilage degeneration and secondary bone hyperplasia. C-reactive protein (CRP) is an acute-phase protein that is widely used as a marker of inflammation. Elevated plasma levels of CRP are commonly observed in patients with OA during the acute phase. Current evidence indicates that CRP dissociating into a monomeric form (mCRP) is the main functional conformation at inflammatory loci. However, it remains unclear whether mCRP is associated with OA and whether mCRP can be used as a biomarker for its pathogenesis. In the present study, the concentration of CRP, mCRP and anti-mCRP autoantibody were detected by performing ELISA. The levels of plasma CRP, mCRP and anti-mCRP autoantibody between healthy subjects and patients with OA were compared. The results revealed that plasma mCRP was strongly associated with OA, while mCRP autoantibodies exhibited little correlation with this condition. Additionally, it was identified that the plasma mCRP levels in Kellgren-Lawrence (KL) grade 4 patients were significantly higher than in those with KL grade 3. Thus, it was revealed in the present study that plasma level of mCRP is associated with OA, which may directly reflect the disease degree of patients. Therefore, mCRP may be a potential indicator that can be used to monitor the disease activity and evaluate the efficiency of OA therapy.
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影响因子：
4.8
作者：
Ji, Shang-Rong;Wu, Yi;Zhao, Jing
通讯作者：
Zhao, Jing
单体 C 反应蛋白结合并中和 NF-κB 配体诱导的破骨细胞分化的受体激活剂
影响因子：
7.3
作者：
Jia ZK;Li HY;Liang YL;Potempa LA;Ji SR;Wu Y
通讯作者：
Wu Y
影响因子：
2.8
作者：
Fernandez-Torres, Javier;Zamudio-Cuevas, Yessica;Angelica Martinez-Nava, Gabriela
通讯作者：
Angelica Martinez-Nava, Gabriela
DOI：
10.1084/jem.190.12.1733
发表时间：
1999-12-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Griselli M;Herbert J;Hutchinson WL;Taylor KM;Sohail M;Krausz T;Pepys MB
通讯作者：
Pepys MB
影响因子：
4.9
作者：
Li Y;Lee PY;Sobel ES;Narain S;Satoh M;Segal MS;Reeves WH;Richards HB
通讯作者：
Richards HB