Protein phosphatases in TLR signaling.
Protein phosphatases in TLR signaling.
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DOI：
10.1186/s12964-021-00722-1
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发表时间：
2021-04-21
期刊：
影响因子：
--
通讯作者：
Hauck CR
中科院分区：
文献类型：
--
作者：
Seumen CHT;Grimm TM;Hauck CR
Toll样受体（TLR）是检测潜在有害微生物的关键传感器。它们有助于启动针对病原生物体的先天性和适应性免疫应答。然而，TLR受体信号传导的过度激活也可能是自身免疫性和炎性疾病发作的原因。虽然TLR信号传导的正调节因子，如蛋白丝氨酸/苏氨酸激酶，已经被深入研究，但对平衡和限制TLR信号传导的磷酸酶知之甚少。在这篇综述中，我们总结了蛋白磷酸化事件及其在TLR通路中的作用，并强调蛋白磷酸酶作为负调节剂参与TLR启动的信号级联反应的特定步骤沿着。然后，我们专注于个别磷酸酶家族，详细说明个别酶在TLR信号传导中的功能，并对未来的研究提出展望。更好地了解磷酸酶介导的TLR信号调节可以提供新的接入点，以减轻过度的免疫激活和调节先天免疫信号。视频摘要在线版本包含补充材料，可通过10.1186/s12964-021-00722-1获取。
Toll-like receptors (TLRs) are critical sensors for the detection of potentially harmful microbes. They are instrumental in initiating innate and adaptive immune responses against pathogenic organisms. However, exaggerated activation of TLR receptor signaling can also be responsible for the onset of autoimmune and inflammatory diseases. While positive regulators of TLR signaling, such as protein serine/threonine kinases, have been studied intensively, only little is known about phosphatases, which counterbalance and limit TLR signaling. In this review, we summarize protein phosphorylation events and their roles in the TLR pathway and highlight the involvement of protein phosphatases as negative regulators at specific steps along the TLR-initiated signaling cascade. Then, we focus on individual phosphatase families, specify the function of individual enzymes in TLR signaling in more detail and give perspectives for future research. A better understanding of phosphatase-mediated regulation of TLR signaling could provide novel access points to mitigate excessive immune activation and to modulate innate immune signaling. Video Abstract The online version contains supplementary material available at 10.1186/s12964-021-00722-1.
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影响因子：
4.6
作者：
Biacchesi S;Mérour E;Chevret D;Lamoureux A;Bernard J;Brémont M
通讯作者：
Brémont M
影响因子：
5.3
作者：
Devin, A;Lin, Y;Liu, ZG
通讯作者：
Liu, ZG
DOI：
10.1016/j.bbrc.2013.05.129
发表时间：
2013-07-05
影响因子：
3.1
作者：
Choi, Hyo-Kyung;Park, Soo-Yeon;Yoon, Ho-Geun
通讯作者：
Yoon, Ho-Geun
DOI：
10.1038/nrmicro2992
发表时间：
2013-04
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
--
影响因子：
16
作者：
Brognard, John;Sierecki, Emma;Newton, Alexandra C.
通讯作者：
Newton, Alexandra C.