Cancer testis antigen vaccination affords long-term protection in a murine model of ovarian cancer.
Cancer testis antigen vaccination affords long-term protection in a murine model of ovarian cancer.
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DOI：
10.1371/journal.pone.0010471
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发表时间：
2010-05-12
期刊：
影响因子：
3.7
通讯作者：
Kast WM
中科院分区：
文献类型：
--
作者：
Chiriva-Internati M;Yu Y;Mirandola L;Jenkins MR;Chapman C;Cannon M;Cobos E;Kast WM
精子蛋白（Sp17）是卵巢癌（OC）疫苗的一个有吸引力的靶点，因为它在原发性和转移性病变中，在疾病的所有阶段都过表达。我们的研究表明，在预防性和治疗性治疗后，基于sp17的疫苗可以诱导具有ID8细胞的C57BL/6小鼠持久防御OC的发生。这是首次发现睾丸癌抗原（Sp17）的小鼠对应物在OC小鼠模型中表达，并且针对该抗原的疫苗接种可显著控制肿瘤生长。我们的研究表明，cpg佐剂的Sp17疫苗克服了免疫耐受问题，这是发展有效的OC免疫治疗的主要障碍。此外，本研究通过显示Th-17细胞活化和当代免疫抑制T-reg细胞抑制是疫苗有效性所必需的，从而更好地了解OC生物学。综上所述，这些结果表明，预防性和治疗性疫苗接种可以诱导对卵巢癌的长期保护，并延缓肿瘤的生长，这表明这种策略可能为人类卵巢癌提供额外的治疗方法，并预防有卵巢癌家族史的女性的疾病发作。
Sperm protein (Sp17) is an attractive target for ovarian cancer (OC) vaccines because of its over-expression in primary as well as in metastatic lesions, at all stages of the disease. Our studies suggest that a Sp17-based vaccine can induce an enduring defense against OC development in C57BL/6 mice with ID8 cells, following prophylactic and therapeutic treatments. This is the first time that a mouse counterpart of a cancer testis antigen (Sp17) was shown to be expressed in an OC mouse model, and that vaccination against this antigen significantly controlled tumor growth. Our study shows that the CpG-adjuvated Sp17 vaccine overcomes the issue of immunologic tolerance, the major barrier to the development of effective immunotherapy for OC. Furthermore, this study provides a better understanding of OC biology by showing that Th-17 cells activation and contemporary immunosuppressive T-reg cells inhibition is required for vaccine efficacy. Taken together, these results indicate that prophylactic and therapeutic vaccinations can induce long-standing protection against OC and delay tumor growth, suggesting that this strategy may provide additional treatments of human OC and the prevention of disease onset in women with a family history of OC.
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精子蛋白17在人类神经系统肿瘤中表达。
影响因子：
3.8
作者：
Grizzi, F;Gaetani, P;Franceschini, B;Di Ieva, A;Colombo, P;Ceva-Grimaldi, G;Bollati, A;Frezza, EE;Cobos, E;Baena, RRY;Dioguardi, N;Chiriva-Internati, M
通讯作者：
Chiriva-Internati, M
影响因子：
15.3
作者：
D'Andrea, A;Aste-Amezaga, M;Valiante, N M;Ma, X;Kubin, M;Trinchieri, G
通讯作者：
Trinchieri, G
影响因子：
3.9
作者：
Chiriva-Internati, Maurizio;Weidanz, Jon A.;Kast, W. Martin
通讯作者：
Kast, W. Martin
影响因子：
20.3
作者：
Kryczek, Ilona;Banerjee, Mousumi;Zou, Weiping
通讯作者：
Zou, Weiping
影响因子：
15.9
作者：
Charles, Kellie A.;Kulbe, Hagen;Hagemann, Thorsten
通讯作者：
Hagemann, Thorsten