Evidence for Extrathymic Changes in the T Cell Receptor Y/b Repertoire
Evidence for Extrathymic Changes in the T Cell Receptor Y/b Repertoire
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T 细胞受体 Y/b 库中胸腺外变化的证据
DOI：
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Brenner
中科院分区：
文献类型：
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作者：
Christina;Parker;Veronika;Groh;Hamid;Band;A. Steven;Porcelli;Craig;Morita;Marina;Fabbi;D. Glass;L. Jack;Strominger;B. Michael;Brenner
淋巴细胞表达两种类型的TCR，a/f（1-3）或y/B（4）。编码TCR γ和B链的基因由V、D、J和C区组成，这些区域在发育过程中经历体细胞重排（5，6）。在人类中仅鉴定出8个功能性Vy基因区段和可能5-10个功能性VS基因区段（6）。尽管对TCR-γ/B的特异性了解甚少，但有限的种系多样性表明，携带TCR-γ/b的淋巴细胞可能在相对非多态性抗原呈递分子的背景下识别抗原（6）。最近，已经描述了对MHC I类和II类基因产物以及I类样基因产物（Tla和Qa）特异的同种异体反应性TCR-γ/B细胞（7-9）。TCR-γ/B的独特性质，携带它的淋巴细胞通常缺乏CD 4和CD 8的事实，以及某些TCR-γ/B细胞对肿瘤靶的非MHC限制性识别（10），使我们认为这些TCR可能识别不在MHC中编码的细胞表面分子（10）。最近证实，人TCR-γ/B克隆可识别非MHC编码的CD 1抗原，其可作为CD 4 -8-T细胞的新型抗原呈递分子（11）。此外，γ/B T细胞可以识别的一些特异性抗原已经被鉴定，例如分枝杆菌抗原（包括热休克蛋白）（12-16）和破伤风类毒素（17）。在淋巴器官和组织病变中，TCR γ/6'淋巴细胞对分枝杆菌抗原的应答在数量上显著增加（13，15）。TCR-γ/B b细胞占人外周血和淋巴组织中CD 3+细胞的0.5-20%（18-20）。然而，在小鼠中，TCR-γ/B细胞更倾向于在小鼠中表达。
Lymphocytes express two types of TCRs, either a/f (1-3) or y/b (4). The genes encoding the TCR y and b chains are composed of V, D, J, and C regions that undergo somatic rearrangement during development (5, 6). There are only eight functional Vy gene segments and perhaps 5-10 functional VS gene segments identified in humans (6). While the specificity ofthe TCR-,y/b is poorly understood, the limited germline diversity suggested that TCR-y/b-bearing lymphocytes might recognize an-tigen in the context of relatively nonpolymorphic antigen-presenting molecules (6). Recently, alloreactive TCR-, y/b cells specific for MHC class I and class II gene products , as well as class I-like gene products (Tla and Qa), have been described (7-9). The distinct nature ofthe TCR-y/b, the fact that lymphocytes that bear it frequently lack CD4 and CD8, and the non-MHC-restricted recognition of tumor targets by some TCR-,y/b cells (10), led us to suggest that these TCRs might recognize cell surface molecules not encoded in the MHC (10). It was recently demonstrated that a human TCR-,y/b clone can recognize non-MHC-encoded CD1 antigens that might serve as novel antigen-presenting molecules for CD4-8-T cells (11). In addition, some of the specific antigens that y/b T cells can recognize have been identified, such as mycobacterial antigens (including heat-shock-proteins) (12-16) and tetanus toxoid (17). TCR-,y/6' lymphocytes expand markedly in number in lymphoid organs and in tissue lesions in response to the mycobacterial antigens (13, 15). TCR-, y/b cells comprise ti5% (0.5-20%) of the CD3+ cells in human peripheral blood and in lymphoid tissues (18-20). However, in mice, TCR-, y/b cells preferen
影响因子：
4.4
作者：
James P. Allison;Bradley W. McIntyre;D. Bloch
通讯作者：
James P. Allison;Bradley W. McIntyre;D. Bloch
使用表达个体人类白细胞共同抗原的转染小鼠细胞系表征 CD45 和 CD45R 单克隆抗体。
DOI：
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发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Streuli,M;Morimoto,C;Schrieber,M;Schlossman,SF;Saito,H
通讯作者：
Saito,H